Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109193695> ?p ?o ?g. }
- W2109193695 endingPage "2197" @default.
- W2109193695 startingPage "2188" @default.
- W2109193695 abstract "Amplification of the HER2 (ErbB2, c-Neu) proto-oncogene in breast cancer is associated with poor prognosis and high relapse rates. HER2/ErbB2, in conjunction with ErbB3, signals through the Akt/phosphatidylinositol 3-kinase pathway and leads to the activation of mammalian target of rapamycin (mTOR), a critical mRNA translation regulator that controls cell growth. Gene expression analysis of mammary tumors collected from mouse mammary tumor virus-c-Neu transgenic mice revealed that mRNA levels of several mTOR pathway members were either up-regulated (p85/phosphatidylinositol 3-kinase and p70S6 kinase) or down-regulated (eIF-4E-BP1) in a manner expected to enhance signaling through this pathway. Treatment of these mice with the mTOR inhibitor rapamycin caused growth arrest and regression of primary tumors with no evidence of weight loss or generalized toxicity. The treatment effects were due to decreased proliferation, associated with reduced cyclin D1 expression, and increased cell death in primary tumors. Whereas many of the dead epithelial cells had the histopathologic characteristics of ischemic necrosis, rapamycin treatment was not associated with changes in microvascular density or apoptosis. Rapamycin also inhibited cellular proliferation in lung metastases. In summary, data from this preclinical model of ErbB2/Neu-induced breast cancer show that inhibition of the mTOR pathway with rapamycin blocks multiple stages of ErbB2/Neu-induced tumorigenic progression." @default.
- W2109193695 created "2016-06-24" @default.
- W2109193695 creator A5004294653 @default.
- W2109193695 creator A5010938832 @default.
- W2109193695 creator A5020136425 @default.
- W2109193695 creator A5068730234 @default.
- W2109193695 creator A5082477755 @default.
- W2109193695 date "2007-08-01" @default.
- W2109193695 modified "2023-09-23" @default.
- W2109193695 title "Rapamycin inhibits multiple stages of c-Neu/ErbB2–induced tumor progression in a transgenic mouse model of HER2-positive breast cancer" @default.
- W2109193695 cites W1964675052 @default.
- W2109193695 cites W1966535797 @default.
- W2109193695 cites W1973555911 @default.
- W2109193695 cites W1982093899 @default.
- W2109193695 cites W1983698019 @default.
- W2109193695 cites W1990208211 @default.
- W2109193695 cites W1994001783 @default.
- W2109193695 cites W1995242599 @default.
- W2109193695 cites W1998682097 @default.
- W2109193695 cites W1998780779 @default.
- W2109193695 cites W2020844485 @default.
- W2109193695 cites W2026351725 @default.
- W2109193695 cites W2037317281 @default.
- W2109193695 cites W2037455744 @default.
- W2109193695 cites W2044424168 @default.
- W2109193695 cites W2058680827 @default.
- W2109193695 cites W2063249691 @default.
- W2109193695 cites W2079816467 @default.
- W2109193695 cites W2086606630 @default.
- W2109193695 cites W2089686996 @default.
- W2109193695 cites W2093607033 @default.
- W2109193695 cites W2098073308 @default.
- W2109193695 cites W2098953839 @default.
- W2109193695 cites W2100885424 @default.
- W2109193695 cites W2101249719 @default.
- W2109193695 cites W2112001957 @default.
- W2109193695 cites W2112893608 @default.
- W2109193695 cites W2115509290 @default.
- W2109193695 cites W2121117803 @default.
- W2109193695 cites W2124156250 @default.
- W2109193695 cites W2126446022 @default.
- W2109193695 cites W2126783165 @default.
- W2109193695 cites W2130348457 @default.
- W2109193695 cites W2131487430 @default.
- W2109193695 cites W2134757689 @default.
- W2109193695 cites W2138710088 @default.
- W2109193695 cites W2141393790 @default.
- W2109193695 cites W2142506125 @default.
- W2109193695 cites W2143897224 @default.
- W2109193695 cites W2145341466 @default.
- W2109193695 cites W2156873226 @default.
- W2109193695 cites W2159121906 @default.
- W2109193695 cites W2162197998 @default.
- W2109193695 cites W2163965347 @default.
- W2109193695 cites W2331525462 @default.
- W2109193695 doi "https://doi.org/10.1158/1535-7163.mct-07-0235" @default.
- W2109193695 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2562754" @default.
- W2109193695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17699716" @default.
- W2109193695 hasPublicationYear "2007" @default.
- W2109193695 type Work @default.
- W2109193695 sameAs 2109193695 @default.
- W2109193695 citedByCount "46" @default.
- W2109193695 countsByYear W21091936952012 @default.
- W2109193695 countsByYear W21091936952013 @default.
- W2109193695 countsByYear W21091936952014 @default.
- W2109193695 countsByYear W21091936952015 @default.
- W2109193695 countsByYear W21091936952017 @default.
- W2109193695 countsByYear W21091936952018 @default.
- W2109193695 countsByYear W21091936952019 @default.
- W2109193695 countsByYear W21091936952020 @default.
- W2109193695 countsByYear W21091936952021 @default.
- W2109193695 countsByYear W21091936952022 @default.
- W2109193695 crossrefType "journal-article" @default.
- W2109193695 hasAuthorship W2109193695A5004294653 @default.
- W2109193695 hasAuthorship W2109193695A5010938832 @default.
- W2109193695 hasAuthorship W2109193695A5020136425 @default.
- W2109193695 hasAuthorship W2109193695A5068730234 @default.
- W2109193695 hasAuthorship W2109193695A5082477755 @default.
- W2109193695 hasBestOaLocation W21091936952 @default.
- W2109193695 hasConcept C102230213 @default.
- W2109193695 hasConcept C104317684 @default.
- W2109193695 hasConcept C121608353 @default.
- W2109193695 hasConcept C141035611 @default.
- W2109193695 hasConcept C184235292 @default.
- W2109193695 hasConcept C199835354 @default.
- W2109193695 hasConcept C2781018059 @default.
- W2109193695 hasConcept C29537977 @default.
- W2109193695 hasConcept C502942594 @default.
- W2109193695 hasConcept C530470458 @default.
- W2109193695 hasConcept C54355233 @default.
- W2109193695 hasConcept C55493867 @default.
- W2109193695 hasConcept C62112901 @default.
- W2109193695 hasConcept C62478195 @default.
- W2109193695 hasConcept C75217442 @default.
- W2109193695 hasConcept C86554907 @default.
- W2109193695 hasConcept C86803240 @default.
- W2109193695 hasConcept C95444343 @default.
- W2109193695 hasConceptScore W2109193695C102230213 @default.