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- W2109200861 endingPage "433" @default.
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- W2109200861 abstract "Gastric cancer is one of the most common causes of cancer death worldwide. P21-activated kinases (PAKs), regulators of cancer-cell signalling networks, play fundamental roles in a range of cellular processes through their binding partners or kinase substrates.The complex regulation of PAKs through their upstream or downstream effectors in human cancers, especially in gastric cancer, are described and the identified inhibitors of PAKs are summarized.The structural differences and activation mechanisms between two subgroups of PAK are described. Both groups of PAKs play complicated and important roles in human gastric cancer, which indicated a possible way for us to identify the specific inhibitors targeting PAKs for gastric cancer.PAKs play important roles in progression of many cancer types, the full mechanisms of PAKs in gastric cancer are still unclear. It seems there are different roles for two groups of PAKs in cancers. Group I PAKs play their functions mostly through their specific substrates, however, many binding partners that are independent of phosphorylation by group II PAKs were identified. Finding specific inhibitors of PAKs will help us discover the roles of PAKs and target these kinases in human gastric cancer." @default.
- W2109200861 created "2016-06-24" @default.
- W2109200861 creator A5061690935 @default.
- W2109200861 creator A5077759445 @default.
- W2109200861 creator A5081844561 @default.
- W2109200861 date "2010-02-10" @default.
- W2109200861 modified "2023-09-30" @default.
- W2109200861 title "PAK as a therapeutic target in gastric cancer" @default.
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