FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109201263> ?p ?o ?g. }

• W2109201263 endingPage "13153" @default.
• W2109201263 startingPage "13150" @default.
• W2109201263 abstract "The quinolone CP-115,953 (6,8-difluoro-7-(4-hydroxyphenyl)-1-cyclopropyl-4- quinolone-3-carboxylic acid) represents a novel mechanistic class of drugs with potent activity against eukaryotic topoisomerase II in vitro (Robinson, M. J., Martin, B. A., Gootz, T. D., McGuirk, P. R., Moynihan, M., Sutcliffe, J. A., and Osheroff, N. (1991) J. Biol. Chem. 266, 14585-14592). Although the quinolone is highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Therefore, yeast was used as a model system to determine whether topoisomerase II is the primary target responsible for the in vivo effects of CP-115,953. The quinolone was equipotent to etoposide at enhancing DNA breakage mediated by the Saccharomyces cerevisiae type II enzyme. Moreover, at concentrations as low as 5 microM, CP-115,953 was cytotoxic to yeast cells that carried wild type topoisomerase II (TOP2+). By utilizing a yeast strain that expressed the top2-1 temperature-sensitive mutant, the effect of topoisomerase II activity on quinolone cytotoxicity was determined. At the permissive temperature of 25 degrees C, cells were highly sensitive to CP-115,953. However, at the semipermissive temperature of 30 degrees C (where in vivo enzyme activity is present but is greatly diminished), cells displayed only marginal sensitivity to the quinolone at concentrations as high as 50 microM. These results strongly suggest that topoisomerase II is the primary physiological target responsible for quinolone cytotoxicity and that CP-115,953 kills cells by converting the type II enzyme into a cellular poison." @default.
• W2109201263 created "2016-06-24" @default.
• W2109201263 creator A5022566853 @default.
• W2109201263 creator A5041320360 @default.
• W2109201263 creator A5071741615 @default.
• W2109201263 date "1992-07-01" @default.
• W2109201263 modified "2023-09-28" @default.
• W2109201263 title "Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target for the quinolone CP-115,953 in yeast." @default.
• W2109201263 cites W147204557 @default.
• W2109201263 cites W1476133568 @default.
• W2109201263 cites W1493562191 @default.
• W2109201263 cites W1543261346 @default.
• W2109201263 cites W1545715398 @default.
• W2109201263 cites W1547587527 @default.
• W2109201263 cites W1570420082 @default.
• W2109201263 cites W1594161662 @default.
• W2109201263 cites W1977754686 @default.
• W2109201263 cites W1979230039 @default.
• W2109201263 cites W1982534799 @default.
• W2109201263 cites W1993553978 @default.
• W2109201263 cites W1994810131 @default.
• W2109201263 cites W1997919079 @default.
• W2109201263 cites W2001121050 @default.
• W2109201263 cites W2012754297 @default.
• W2109201263 cites W2027095809 @default.
• W2109201263 cites W2029028808 @default.
• W2109201263 cites W2032541732 @default.
• W2109201263 cites W2058911936 @default.
• W2109201263 cites W2066459366 @default.
• W2109201263 cites W2074651320 @default.
• W2109201263 cites W2083153561 @default.
• W2109201263 cites W2093668404 @default.
• W2109201263 cites W2102345056 @default.
• W2109201263 cites W2125009595 @default.
• W2109201263 cites W2142775912 @default.
• W2109201263 cites W2171672489 @default.
• W2109201263 cites W2319438985 @default.
• W2109201263 cites W4233567369 @default.
• W2109201263 doi "https://doi.org/10.1016/s0021-9258(18)42185-0" @default.
• W2109201263 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1320012" @default.
• W2109201263 hasPublicationYear "1992" @default.
• W2109201263 type Work @default.
• W2109201263 sameAs 2109201263 @default.
• W2109201263 citedByCount "103" @default.
• W2109201263 countsByYear W21092012632012 @default.
• W2109201263 countsByYear W21092012632013 @default.
• W2109201263 countsByYear W21092012632014 @default.
• W2109201263 countsByYear W21092012632015 @default.
• W2109201263 countsByYear W21092012632016 @default.
• W2109201263 countsByYear W21092012632017 @default.
• W2109201263 countsByYear W21092012632018 @default.
• W2109201263 countsByYear W21092012632019 @default.
• W2109201263 countsByYear W21092012632020 @default.
• W2109201263 countsByYear W21092012632021 @default.
• W2109201263 countsByYear W21092012632023 @default.
• W2109201263 crossrefType "journal-article" @default.
• W2109201263 hasAuthorship W2109201263A5022566853 @default.
• W2109201263 hasAuthorship W2109201263A5041320360 @default.
• W2109201263 hasAuthorship W2109201263A5071741615 @default.
• W2109201263 hasBestOaLocation W21092012631 @default.
• W2109201263 hasConcept C109316439 @default.
• W2109201263 hasConcept C121332964 @default.
• W2109201263 hasConcept C1276947 @default.
• W2109201263 hasConcept C147897179 @default.
• W2109201263 hasConcept C185592680 @default.
• W2109201263 hasConcept C202751555 @default.
• W2109201263 hasConcept C2777977315 @default.
• W2109201263 hasConcept C2779222958 @default.
• W2109201263 hasConcept C2779922871 @default.
• W2109201263 hasConcept C501593827 @default.
• W2109201263 hasConcept C552990157 @default.
• W2109201263 hasConcept C55493867 @default.
• W2109201263 hasConcept C86803240 @default.
• W2109201263 hasConcept C98274493 @default.
• W2109201263 hasConceptScore W2109201263C109316439 @default.
• W2109201263 hasConceptScore W2109201263C121332964 @default.
• W2109201263 hasConceptScore W2109201263C1276947 @default.
• W2109201263 hasConceptScore W2109201263C147897179 @default.
• W2109201263 hasConceptScore W2109201263C185592680 @default.
• W2109201263 hasConceptScore W2109201263C202751555 @default.
• W2109201263 hasConceptScore W2109201263C2777977315 @default.
• W2109201263 hasConceptScore W2109201263C2779222958 @default.
• W2109201263 hasConceptScore W2109201263C2779922871 @default.
• W2109201263 hasConceptScore W2109201263C501593827 @default.
• W2109201263 hasConceptScore W2109201263C552990157 @default.
• W2109201263 hasConceptScore W2109201263C55493867 @default.
• W2109201263 hasConceptScore W2109201263C86803240 @default.
• W2109201263 hasConceptScore W2109201263C98274493 @default.
• W2109201263 hasIssue "19" @default.
• W2109201263 hasLocation W21092012631 @default.
• W2109201263 hasOpenAccess W2109201263 @default.
• W2109201263 hasPrimaryLocation W21092012631 @default.
• W2109201263 hasRelatedWork W2037614885 @default.
• W2109201263 hasRelatedWork W2054837357 @default.
• W2109201263 hasRelatedWork W2087450993 @default.
• W2109201263 hasRelatedWork W2298555402 @default.
• W2109201263 hasRelatedWork W2313851167 @default.
• W2109201263 hasRelatedWork W2364762990 @default.

• next