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• W2109208815 endingPage "e73" @default.
• W2109208815 startingPage "e60" @default.
• W2109208815 abstract "The opportunistic yeast pathogen Candida albicans and the emerging non-albicans Candida spp. cause life-threatening infections in immuno-compromised patients, leading to an increase in mortality rate. At present, the emergence of non-albicans Candida spp. causes serious infections that are difficult to treat the human populations worldwide. The available, synthetic antifungal drugs show high toxicity to host tissues causing adverse effects. Many metabolites of terrestrial and marine plants, microbes, algae, etc., contain a rich source of unexplored novel leads of different types, which are under use to treat various diseases. Such natural drugs are less expensive and have lower toxicity to host tissues. The patent search on identified and potential anticandidal-lead molecules, from various patent databases, has been described in this review. Furthermore, this article consolidates the trends in the development of anticandidal drug discovery worldwide. Most of the investigations on natural, bioactive molecules against candidiasis are in various phases of clinical trials, of which, two drugs Caspofungin acetate and Micafungin sodium were approved by the U.S. FDA. In conclusion, the exploration of drugs from natural resources serves as a better alternative source in anticandidal therapeutics, having great scope for drug discovery in the future." @default.
• W2109208815 created "2016-06-24" @default.
• W2109208815 creator A5019444692 @default.
• W2109208815 creator A5086304924 @default.
• W2109208815 date "2011-11-25" @default.
• W2109208815 modified "2023-09-26" @default.
• W2109208815 title "Emergence of Candida spp. and exploration of natural bioactive molecules for anticandidal therapy -status quo" @default.
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• W2109208815 doi "https://doi.org/10.1111/j.1439-0507.2011.02156.x" @default.
• W2109208815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22118661" @default.
• W2109208815 hasPublicationYear "2011" @default.
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