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• W2109221199 abstract "The proto-oncogene c-Myc is involved in early neoplastic transformations. Two consensus Lef/Tcf binding elements (TBE) were found to be prerequisite for transcriptional transactivation by the armadillo proteins β-catenin and plakoglobin (PG) together with Tcf4 in human neoplastic cells. In epidermal keratinocytes, c-Myc was reported to be repressed by Lef-1 and PG. Using reporter gene assays, here we demonstrate that deletion of the two consensus TBE fails to abrogate transcriptional regulation by Lef-1/PG in wildtype and β-catenin−/− keratinocytes, while it reduces transcription in pre-neoplastic PG−/− keratinocytes. We identified a TBE sequence variant downstream of the major transcriptional initiation site that binds Lef-1 in vitro and in vivo, and its mutation compromised transcriptional regulation by Lef-1/PG. Collectively, this study demonstrates that the two consensus TBE's reported in neoplastic cells are dispensable for c-Myc regulation in normal keratinocytes, which instead use a novel TBE sequence variant. This unprecedented finding may have important implications for armadillo target genes involved in carcinogenesis." @default.
• W2109221199 created "2016-06-24" @default.
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• W2109221199 date "2007-04-20" @default.
• W2109221199 modified "2023-10-14" @default.
• W2109221199 title "Keratinocyte transcriptional regulation of the human c-Myc promoter occurs via a novel Lef/Tcf binding element distinct from neoplastic cells" @default.
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• W2109221199 doi "https://doi.org/10.1016/j.febslet.2007.04.023" @default.
• W2109221199 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17466981" @default.
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