FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109223684> ?p ?o ?g. }

• W2109223684 endingPage "1531" @default.
• W2109223684 startingPage "1520" @default.
• W2109223684 abstract "Bacterial infection with group B Streptococcus (GBS) represents a prominent threat to neonates and fetuses in the Western world, causing severe organ damage and even death. To improve current therapeutic strategies and to investigate new approaches, an appropriate in vivo model to study the immune response of a human immune system is needed. Therefore, we introduced humanized mice as a new model for GBS-induced sepsis. Humanized mice feature deficiencies similar to those found in neonates, such as lower immunoglobulin levels and myeloid cell dysfunction. Due to the husbandry in specific-pathogen-free (SPF) facilities, the human immune cells in these mice also exhibit a naive phenotype which mimics the conditions in fetuses/neonates. Following infection, cytokine release and leukocyte trafficking from the bone marrow to the lymphoid organ (spleen) and into the peritoneum (site of infection) as well as bacterial spreading and clearance were traceable in the humanized mice. Furthermore, we investigated the effects of betamethasone and indomethacin treatment using this novel sepsis model. Although both drugs are commonly used in perinatal care, little is known about their effects on the neonatal immune system. Treatment of infected humanized mice not only induced the reduction of human leukocytes in the spleen but also increased the bacterial load in all analyzed organs, including the brain, which did not show infiltration of live GBS in untreated controls. These studies demonstrate the utility of the humanized mice as a new model to study an immature human immune response during bacterial infection and allow the investigation of side effects induced by various treatments." @default.
• W2109223684 created "2016-06-24" @default.
• W2109223684 creator A5007118863 @default.
• W2109223684 creator A5025503541 @default.
• W2109223684 creator A5051752309 @default.
• W2109223684 creator A5075822843 @default.
• W2109223684 creator A5079273157 @default.
• W2109223684 creator A5082692607 @default.
• W2109223684 date "2013-05-01" @default.
• W2109223684 modified "2023-10-18" @default.
• W2109223684 title "Humanized Mice, a New Model To Study the Influence of Drug Treatment on Neonatal Sepsis" @default.
• W2109223684 cites W125502923 @default.
• W2109223684 cites W1497550398 @default.
• W2109223684 cites W1551102474 @default.
• W2109223684 cites W1587912669 @default.
• W2109223684 cites W1731514419 @default.
• W2109223684 cites W1869217923 @default.
• W2109223684 cites W1916563986 @default.
• W2109223684 cites W1964900947 @default.
• W2109223684 cites W1973754994 @default.
• W2109223684 cites W1982865894 @default.
• W2109223684 cites W1990036222 @default.
• W2109223684 cites W1997611976 @default.
• W2109223684 cites W2001578637 @default.
• W2109223684 cites W2002609417 @default.
• W2109223684 cites W2005599815 @default.
• W2109223684 cites W2006468572 @default.
• W2109223684 cites W2008439902 @default.
• W2109223684 cites W2012001933 @default.
• W2109223684 cites W2019043807 @default.
• W2109223684 cites W2019579176 @default.
• W2109223684 cites W2019848134 @default.
• W2109223684 cites W2024123171 @default.
• W2109223684 cites W2024479590 @default.
• W2109223684 cites W2027759577 @default.
• W2109223684 cites W2033548186 @default.
• W2109223684 cites W2039807525 @default.
• W2109223684 cites W2040257510 @default.
• W2109223684 cites W2048000158 @default.
• W2109223684 cites W2053771766 @default.
• W2109223684 cites W2054542585 @default.
• W2109223684 cites W2057148382 @default.
• W2109223684 cites W2057964010 @default.
• W2109223684 cites W2060614647 @default.
• W2109223684 cites W2065290731 @default.
• W2109223684 cites W2069841224 @default.
• W2109223684 cites W2073341825 @default.
• W2109223684 cites W2079738088 @default.
• W2109223684 cites W2085241965 @default.
• W2109223684 cites W2089925145 @default.
• W2109223684 cites W2094502172 @default.
• W2109223684 cites W2098324424 @default.
• W2109223684 cites W2101614234 @default.
• W2109223684 cites W2106125905 @default.
• W2109223684 cites W2106481624 @default.
• W2109223684 cites W2109963121 @default.
• W2109223684 cites W2113982219 @default.
• W2109223684 cites W2120909821 @default.
• W2109223684 cites W2127621667 @default.
• W2109223684 cites W2129079335 @default.
• W2109223684 cites W2132155942 @default.
• W2109223684 cites W2132278819 @default.
• W2109223684 cites W2134702933 @default.
• W2109223684 cites W2139050492 @default.
• W2109223684 cites W2141989396 @default.
• W2109223684 cites W2145254159 @default.
• W2109223684 cites W2150928170 @default.
• W2109223684 cites W2153112971 @default.
• W2109223684 cites W2153756100 @default.
• W2109223684 cites W2158385322 @default.
• W2109223684 cites W2170501593 @default.
• W2109223684 cites W4254710724 @default.
• W2109223684 doi "https://doi.org/10.1128/iai.01235-12" @default.
• W2109223684 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3647987" @default.
• W2109223684 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23439310" @default.
• W2109223684 hasPublicationYear "2013" @default.
• W2109223684 type Work @default.
• W2109223684 sameAs 2109223684 @default.
• W2109223684 citedByCount "31" @default.
• W2109223684 countsByYear W21092236842013 @default.
• W2109223684 countsByYear W21092236842014 @default.
• W2109223684 countsByYear W21092236842015 @default.
• W2109223684 countsByYear W21092236842016 @default.
• W2109223684 countsByYear W21092236842017 @default.
• W2109223684 countsByYear W21092236842018 @default.
• W2109223684 countsByYear W21092236842019 @default.
• W2109223684 countsByYear W21092236842020 @default.
• W2109223684 countsByYear W21092236842021 @default.
• W2109223684 countsByYear W21092236842022 @default.
• W2109223684 countsByYear W21092236842023 @default.
• W2109223684 crossrefType "journal-article" @default.
• W2109223684 hasAuthorship W2109223684A5007118863 @default.
• W2109223684 hasAuthorship W2109223684A5025503541 @default.
• W2109223684 hasAuthorship W2109223684A5051752309 @default.
• W2109223684 hasAuthorship W2109223684A5075822843 @default.
• W2109223684 hasAuthorship W2109223684A5079273157 @default.
• W2109223684 hasAuthorship W2109223684A5082692607 @default.
• W2109223684 hasBestOaLocation W21092236841 @default.

• next