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- W2109224630 abstract "Background: Photodegradation of certain vitamins such as riboflavins, carotenoids, tocopherol, and folate has been welldocumented. Previous observations suggest that photochemotherapy (PUVA) may cause folate deficiency. This is of great importance since folate deficiency has important health consequences and has been linked with the development of neural tube defects. UVB Phototherapy is generally recommended by dermatologists as safe to use in pregnant women. Studies on UVB-induced alterations of serum folate levels have not been conducted. Objective: Investigating the influence of UVB radiation on serum folate levels in vivo. Methods: Twenty patients undergoing narrow band UVB (NB UVB) phototherapy as well as 20 healthy volunteers were enrolled into the study after excluding factors known to influence serum folate concentrations. Serum folate was analyzed in all subjects at baseline, and after 36 NB UVB exposures in treated patients. Three UVB exposures were performed weekly within 12 weeks (mean cumulative NB UVB dose: 75.95±3.67 J/cm2). Results: Serum folate values were statistically significantly lower in patients at the end of the study compared to their baseline and control levels. Conclusion: Cumulative UVB exposure may induce folate catabolism and simultaneous folate deficiency." @default.
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- W2109224630 date "2006-01-01" @default.
- W2109224630 modified "2023-09-27" @default.
- W2109224630 title "Analysis of Serum Folate Levels after Narrow Band UVB Exposure" @default.
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