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• W2109233281 abstract "Background. Kleiber’s law describes the quantitative association between whole-body resting energy expenditure (REE, in kcal/d) and body mass ( M , in kg) across mature mammals as REE <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo>=</mml:mo><mml:mn>70.0</mml:mn><mml:mo>×</mml:mo><mml:msup><mml:mrow><mml:mi>M</mml:mi></mml:mrow><mml:mrow><mml:mn>0.75</mml:mn></mml:mrow></mml:msup></mml:math>. The basis of this empirical function is uncertain. Objectives. The study objective was to establish an organ-tissue level REE model across mammals and to explore the body composition and physiologic basis of Kleiber’s law. Design. We evaluated the hypothesis that REE in mature mammals can be predicted by a combination of two variables: the mass of individual organs/tissues and their corresponding specific resting metabolic rates. Data on the mass of organs with high metabolic rate (i.e., liver, brain, heart, and kidneys) for 111 species ranging in body mass from 0.0075 (shrew) to 6650 kg (elephant) were obtained from a literature review. Results. <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> predicted by the organ-tissue level model was correlated with body mass (correlation <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.9975</mml:mn></mml:math>) and resulted in the function <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub><mml:mo>=</mml:mo><mml:mn mathvariant=normal>66.33</mml:mn><mml:mo>×</mml:mo><mml:msup><mml:mrow><mml:mi>M</mml:mi></mml:mrow><mml:mrow><mml:mn mathvariant=normal>0.754</mml:mn></mml:mrow></mml:msup></mml:math>, with a coefficient and scaling exponent, respectively, close to 70.0 and 0.75 (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M5><mml:mi>P</mml:mi><mml:mo>></mml:mo><mml:mn>0.05</mml:mn></mml:math>) as observed by Kleiber. There were no differences between <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M6><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> and <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M7><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>k</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> calculated by Kleiber’s law; <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M8><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math> was correlated (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M9><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.9994</mml:mn></mml:math>) with <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M10><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>k</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>. The mass-specific <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M11><mml:mrow><mml:msub><mml:mrow><mml:mtext>REE</mml:mtext></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, that is, <mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M12><mml:mrow><mml:msub><mml:mrow><mml:mo stretchy=false>(</mml:mo><mml:mtext>REE</mml:mtext><mml:mo>/</mml:mo><mml:mi>M</mml:mi><mml:mo stretchy=false>)</mml:mo></mml:mrow><mml:mrow><mml:mi>p</mml:mi></mml:mrow></mml:msub></mml:mrow></mml:math>, was correlated with body mass (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M13><mml:mi>r</mml:mi><mml:mo>=</mml:mo><mml:mn>0.9779</mml:mn></mml:math>) with a scaling exponent −0.246, close to −0.25 as observed with Kleiber’s law. Conclusion. Our findings provide new insights into the organ/tissue energetic components of Kleiber’s law. The observed large rise in REE and lowering of REE/ M from shrew to elephant can be explained by corresponding changes in organ/tissue mass and associated specific metabolic rate." @default.
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• W2109233281 date "2012-09-26" @default.
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• W2109233281 title "Organ-Tissue Level Model of Resting Energy Expenditure Across Mammals: New Insights into Kleiber's Law" @default.
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