FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109235556> ?p ?o ?g. }

• W2109235556 endingPage "1906" @default.
• W2109235556 startingPage "1902" @default.
• W2109235556 abstract "Although several epidemiologic studies have shown that gamma-glutamyltransferase (GGT) is associated with cardiovascular disease and all-cause mortality, its relationship with cancer incidence remains widely unexplored. In experimental models the ability of cellular GGT to modulate crucial redox-sensitive functions has been established, and it may thus play a role in tumor progression. In the present study, we investigated the association of GGT with overall and site-specific cancer incidence in a population-based cohort of 92,843 Austrian women with 349,674 serial GGT measurements, prospectively followed-up for a median of 13.5 years. The relationship between GGT and cancer incidence was analyzed using adjusted Cox regression models with age as underlying time metric with age as underlying time metric including GGT concentrations at baseline and incorporating repeated GGT measurements as a time-dependent variable. During follow-up, 4,884 incidence cancers were observed. Compared to normal low GGT (<17.99 U/L), cancer risk was elevated for all other GGT categories (p for trend < 0.0001), with adjusted hazard ratios (95% confidence intervals) of 1.06 (0.99–1.13) for GGT levels between 18.00 and 35.99 U/L (normal high), 1.12 (1.02–1.22) for GGT levels between 36.00 and 71.99 U/L (elevated) and 1.43 (1.28–1.61) for highly elevated GGT (>72.00 U/L). Very similar results were seen when GGT was analyzed as a time-dependent variable. In cancer-site specific models, elevated GGT statistically significantly increased the risk for malignant neoplasms of digestive organs, the respiratory system/intrathoracic organs, breast and female genital organs and lymphoid and haematopoietic cancers (all, p < 0.006). Our study is the first to demonstrate in a large population-based cohort that high GGT levels significantly increased cancer risk in women. Published 2008 Wiley-Liss, Inc." @default.
• W2109235556 created "2016-06-24" @default.
• W2109235556 creator A5004500883 @default.
• W2109235556 creator A5019003637 @default.
• W2109235556 creator A5031334599 @default.
• W2109235556 creator A5037297600 @default.
• W2109235556 creator A5048492462 @default.
• W2109235556 creator A5050869737 @default.
• W2109235556 creator A5060973508 @default.
• W2109235556 creator A5065170492 @default.
• W2109235556 creator A5070059600 @default.
• W2109235556 creator A5074892585 @default.
• W2109235556 creator A5091894637 @default.
• W2109235556 date "2008-10-15" @default.
• W2109235556 modified "2023-10-12" @default.
• W2109235556 title "Prospective study of the association of gamma-glutamyltransferase with cancer incidence in women" @default.
• W2109235556 cites W1570622790 @default.
• W2109235556 cites W1929345885 @default.
• W2109235556 cites W1950940723 @default.
• W2109235556 cites W1967165702 @default.
• W2109235556 cites W1977338615 @default.
• W2109235556 cites W1982226024 @default.
• W2109235556 cites W1984409264 @default.
• W2109235556 cites W2002194181 @default.
• W2109235556 cites W2009072976 @default.
• W2109235556 cites W2009663493 @default.
• W2109235556 cites W2010866554 @default.
• W2109235556 cites W2014393059 @default.
• W2109235556 cites W2015888932 @default.
• W2109235556 cites W2020720230 @default.
• W2109235556 cites W2030847564 @default.
• W2109235556 cites W2032913011 @default.
• W2109235556 cites W2054457100 @default.
• W2109235556 cites W2057827776 @default.
• W2109235556 cites W2082465243 @default.
• W2109235556 cites W2094171279 @default.
• W2109235556 cites W2098470100 @default.
• W2109235556 cites W2103002222 @default.
• W2109235556 cites W2104850628 @default.
• W2109235556 cites W2110267763 @default.
• W2109235556 cites W2111408436 @default.
• W2109235556 cites W2116888647 @default.
• W2109235556 cites W2127510700 @default.
• W2109235556 cites W2131703110 @default.
• W2109235556 cites W2140965288 @default.
• W2109235556 cites W2143992598 @default.
• W2109235556 cites W2146122808 @default.
• W2109235556 cites W2152446214 @default.
• W2109235556 cites W2157224977 @default.
• W2109235556 cites W2157422924 @default.
• W2109235556 cites W2166000887 @default.
• W2109235556 cites W2170989176 @default.
• W2109235556 cites W2259862678 @default.
• W2109235556 cites W2282166293 @default.
• W2109235556 cites W2336361163 @default.
• W2109235556 doi "https://doi.org/10.1002/ijc.23714" @default.
• W2109235556 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18688855" @default.
• W2109235556 hasPublicationYear "2008" @default.
• W2109235556 type Work @default.
• W2109235556 sameAs 2109235556 @default.
• W2109235556 citedByCount "84" @default.
• W2109235556 countsByYear W21092355562012 @default.
• W2109235556 countsByYear W21092355562013 @default.
• W2109235556 countsByYear W21092355562014 @default.
• W2109235556 countsByYear W21092355562015 @default.
• W2109235556 countsByYear W21092355562016 @default.
• W2109235556 countsByYear W21092355562017 @default.
• W2109235556 countsByYear W21092355562018 @default.
• W2109235556 countsByYear W21092355562019 @default.
• W2109235556 countsByYear W21092355562020 @default.
• W2109235556 countsByYear W21092355562021 @default.
• W2109235556 countsByYear W21092355562022 @default.
• W2109235556 countsByYear W21092355562023 @default.
• W2109235556 crossrefType "journal-article" @default.
• W2109235556 hasAuthorship W2109235556A5004500883 @default.
• W2109235556 hasAuthorship W2109235556A5019003637 @default.
• W2109235556 hasAuthorship W2109235556A5031334599 @default.
• W2109235556 hasAuthorship W2109235556A5037297600 @default.
• W2109235556 hasAuthorship W2109235556A5048492462 @default.
• W2109235556 hasAuthorship W2109235556A5050869737 @default.
• W2109235556 hasAuthorship W2109235556A5060973508 @default.
• W2109235556 hasAuthorship W2109235556A5065170492 @default.
• W2109235556 hasAuthorship W2109235556A5070059600 @default.
• W2109235556 hasAuthorship W2109235556A5074892585 @default.
• W2109235556 hasAuthorship W2109235556A5091894637 @default.
• W2109235556 hasBestOaLocation W21092355561 @default.
• W2109235556 hasConcept C120665830 @default.
• W2109235556 hasConcept C121332964 @default.
• W2109235556 hasConcept C121608353 @default.
• W2109235556 hasConcept C126322002 @default.
• W2109235556 hasConcept C143998085 @default.
• W2109235556 hasConcept C181199279 @default.
• W2109235556 hasConcept C188816634 @default.
• W2109235556 hasConcept C201903717 @default.
• W2109235556 hasConcept C207103383 @default.
• W2109235556 hasConcept C2781278919 @default.
• W2109235556 hasConcept C2908647359 @default.
• W2109235556 hasConcept C44249647 @default.

• next