Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109254890> ?p ?o ?g. }
- W2109254890 abstract "Malignant peripheral nerve sheath tumour (MPNST) is a rare malignancy accounting for 3–10% of all soft tissue sarcomas. Most MPNSTs arise in association with peripheral nerves or deep neurofibromas and may originate from neural crest cells, although the specific cell of origin is uncertain. Approximately half of MPNSTs occur in the setting of neurofibromatosis type 1 (NF1), an autosomal dominant disorder with an incidence of approximately one in 3500 persons; the remainder of MPNSTs develop sporadically. In addition to a variety of clinical manifestations, approximately 8–13% of NF1 patients develop MPNSTs, which are the leading cause of NF1-related mortality. Surgical resection is the mainstay of MPNST clinical management. However, because of invasive growth, propensity to metastasise, and limited sensitivity to chemotherapy and radiation, MPNST has a guarded to poor prognosis. Five-year survival rates of only 20–50% indicate an urgent need for improved therapeutic approaches. Recent work in this field has identified several altered intracellular signal transduction cascades and deregulated tyrosine kinase receptors, posing the possibility of personalised, targeted therapeutics. However, expanded knowledge of MPNST molecular pathobiology will be needed to meaningfully apply such approaches for the benefit of afflicted patients." @default.
- W2109254890 created "2016-06-24" @default.
- W2109254890 creator A5050445982 @default.
- W2109254890 creator A5065854516 @default.
- W2109254890 creator A5088025233 @default.
- W2109254890 date "2009-10-01" @default.
- W2109254890 modified "2023-09-27" @default.
- W2109254890 title "Malignant peripheral nerve sheath tumour (MPNST): the clinical implications of cellular signalling pathways" @default.
- W2109254890 cites W1557061959 @default.
- W2109254890 cites W1588935895 @default.
- W2109254890 cites W1606749110 @default.
- W2109254890 cites W1963717756 @default.
- W2109254890 cites W1964746270 @default.
- W2109254890 cites W1967644074 @default.
- W2109254890 cites W1971158504 @default.
- W2109254890 cites W1971602793 @default.
- W2109254890 cites W1971656848 @default.
- W2109254890 cites W1974184999 @default.
- W2109254890 cites W1974408717 @default.
- W2109254890 cites W1975653248 @default.
- W2109254890 cites W1975702431 @default.
- W2109254890 cites W1976221241 @default.
- W2109254890 cites W1988409513 @default.
- W2109254890 cites W1990201158 @default.
- W2109254890 cites W1992013240 @default.
- W2109254890 cites W2005274511 @default.
- W2109254890 cites W2005496215 @default.
- W2109254890 cites W2005690449 @default.
- W2109254890 cites W2006211674 @default.
- W2109254890 cites W2007927189 @default.
- W2109254890 cites W2008597053 @default.
- W2109254890 cites W2010590846 @default.
- W2109254890 cites W2011425688 @default.
- W2109254890 cites W2012459207 @default.
- W2109254890 cites W2014050032 @default.
- W2109254890 cites W2017793525 @default.
- W2109254890 cites W2019687915 @default.
- W2109254890 cites W2021788227 @default.
- W2109254890 cites W2025568716 @default.
- W2109254890 cites W2026351725 @default.
- W2109254890 cites W202730752 @default.
- W2109254890 cites W2027631295 @default.
- W2109254890 cites W2030941618 @default.
- W2109254890 cites W2031892485 @default.
- W2109254890 cites W2032220244 @default.
- W2109254890 cites W2033991249 @default.
- W2109254890 cites W2034480902 @default.
- W2109254890 cites W2041098455 @default.
- W2109254890 cites W2042552060 @default.
- W2109254890 cites W2044356784 @default.
- W2109254890 cites W2045587342 @default.
- W2109254890 cites W2045722716 @default.
- W2109254890 cites W2047818921 @default.
- W2109254890 cites W2048140690 @default.
- W2109254890 cites W2049219210 @default.
- W2109254890 cites W2050965311 @default.
- W2109254890 cites W2053280162 @default.
- W2109254890 cites W2053442386 @default.
- W2109254890 cites W2054674800 @default.
- W2109254890 cites W2057767074 @default.
- W2109254890 cites W2058233029 @default.
- W2109254890 cites W2060157525 @default.
- W2109254890 cites W2063057728 @default.
- W2109254890 cites W2063373358 @default.
- W2109254890 cites W2063755666 @default.
- W2109254890 cites W2064377189 @default.
- W2109254890 cites W2069886811 @default.
- W2109254890 cites W2071816418 @default.
- W2109254890 cites W2073355522 @default.
- W2109254890 cites W2074320525 @default.
- W2109254890 cites W2074433596 @default.
- W2109254890 cites W2074683216 @default.
- W2109254890 cites W2075091190 @default.
- W2109254890 cites W2079430799 @default.
- W2109254890 cites W2085190470 @default.
- W2109254890 cites W2088202919 @default.
- W2109254890 cites W2088796820 @default.
- W2109254890 cites W2089726034 @default.
- W2109254890 cites W2093638795 @default.
- W2109254890 cites W2097092521 @default.
- W2109254890 cites W2097146615 @default.
- W2109254890 cites W2098114704 @default.
- W2109254890 cites W2098635239 @default.
- W2109254890 cites W2100516555 @default.
- W2109254890 cites W2100589633 @default.
- W2109254890 cites W2102148658 @default.
- W2109254890 cites W2104152920 @default.
- W2109254890 cites W2107078161 @default.
- W2109254890 cites W2107791134 @default.
- W2109254890 cites W2107942104 @default.
- W2109254890 cites W2110444464 @default.
- W2109254890 cites W2114048774 @default.
- W2109254890 cites W2115484306 @default.
- W2109254890 cites W2117558653 @default.
- W2109254890 cites W2119843301 @default.
- W2109254890 cites W2121733985 @default.
- W2109254890 cites W2122184474 @default.
- W2109254890 cites W2127150495 @default.
- W2109254890 cites W2127329372 @default.
- W2109254890 cites W2130521145 @default.