FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109257550> ?p ?o ?g. }

• W2109257550 endingPage "3309" @default.
• W2109257550 startingPage "3300" @default.
• W2109257550 abstract "FcvarepsilonRIalpha found on the surface of mast cells and basophiles mediates allergic diseases, anaphylaxis and asthma through binding of IgE. Disrupting this interaction with anti-IgE mAbs has proven an efficient approach to control these diseases. The crystallographic structure of the complex formed between the IgE-Fc and FcvarepsilonRIalpha extracellular domain has shown that recognition is mediated by residues in the second Ig-like domain of the receptor (D2) and in the loop connecting the D1 and D2 domains. In an attempt to obtain specific IgE antagonists, we have designed and prepared a polypeptide named IgE-Trap that partially reproduces the IgE receptor-binding sites and binds with micromolar affinity to soluble IgE. The polypeptide contains loops C'-E [residues 129-134] and F-G [residues 151-161] from the D2 domain joined by a linker, and loop B-C [residues 110-113]. Peptide binding to IgE has been assessed by SPR analyses and the data fit with a biphasic model of interaction, in agreement with the two-site mechanism reported for the native receptor. The polypeptide binds to immobilized IgE in a dose-dependent manner with a K(D) estimated to be around 6muM, while it does not recognize IgG nor IgA. Polypeptide sub-domains involved in IgE binding have also been defined, showing that loop C'-E connected to loop B-C, but also the isolated loop B-C alone suffice to bind immunoglobulins E with high selectively though with reduced affinity compared to IgE-Trap. ELISA and cytometric assays on RBL2H3 cells demonstrate that the interacting peptides are able to displace the binding of IgE to receptor, confirming affinity and specificity of these ligands and suggesting a potential application as modulators of disorders associated with inappropriate IgE production." @default.
• W2109257550 created "2016-06-24" @default.
• W2109257550 creator A5016208813 @default.
• W2109257550 creator A5025518286 @default.
• W2109257550 creator A5032929570 @default.
• W2109257550 creator A5048971494 @default.
• W2109257550 creator A5074325380 @default.
• W2109257550 creator A5076045755 @default.
• W2109257550 creator A5087351584 @default.
• W2109257550 date "2009-10-01" @default.
• W2109257550 modified "2023-10-16" @default.
• W2109257550 title "IgE-binding properties and selectivity of peptide mimics of the FcɛRI binding site" @default.
• W2109257550 cites W1544611381 @default.
• W2109257550 cites W1576093064 @default.
• W2109257550 cites W1597223624 @default.
• W2109257550 cites W1857685991 @default.
• W2109257550 cites W1967350661 @default.
• W2109257550 cites W1968226880 @default.
• W2109257550 cites W1968542364 @default.
• W2109257550 cites W1973047319 @default.
• W2109257550 cites W1973957435 @default.
• W2109257550 cites W1979911075 @default.
• W2109257550 cites W1986493103 @default.
• W2109257550 cites W1990160588 @default.
• W2109257550 cites W1996993404 @default.
• W2109257550 cites W2002037026 @default.
• W2109257550 cites W2002062272 @default.
• W2109257550 cites W2010809813 @default.
• W2109257550 cites W2023115564 @default.
• W2109257550 cites W2025072888 @default.
• W2109257550 cites W2026188247 @default.
• W2109257550 cites W2033330205 @default.
• W2109257550 cites W2035391351 @default.
• W2109257550 cites W2037455416 @default.
• W2109257550 cites W2055496655 @default.
• W2109257550 cites W2055626137 @default.
• W2109257550 cites W2060545946 @default.
• W2109257550 cites W2062216746 @default.
• W2109257550 cites W2064719289 @default.
• W2109257550 cites W2072873508 @default.
• W2109257550 cites W2075894776 @default.
• W2109257550 cites W2090830590 @default.
• W2109257550 cites W2119256134 @default.
• W2109257550 cites W2128561746 @default.
• W2109257550 cites W2137404654 @default.
• W2109257550 cites W2159320790 @default.
• W2109257550 cites W2325403942 @default.
• W2109257550 cites W2430242855 @default.
• W2109257550 cites W271097414 @default.
• W2109257550 cites W4241138016 @default.
• W2109257550 doi "https://doi.org/10.1016/j.molimm.2009.07.025" @default.
• W2109257550 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19699527" @default.
• W2109257550 hasPublicationYear "2009" @default.
• W2109257550 type Work @default.
• W2109257550 sameAs 2109257550 @default.
• W2109257550 citedByCount "14" @default.
• W2109257550 countsByYear W21092575502012 @default.
• W2109257550 countsByYear W21092575502013 @default.
• W2109257550 countsByYear W21092575502014 @default.
• W2109257550 countsByYear W21092575502015 @default.
• W2109257550 countsByYear W21092575502016 @default.
• W2109257550 countsByYear W21092575502017 @default.
• W2109257550 countsByYear W21092575502020 @default.
• W2109257550 crossrefType "journal-article" @default.
• W2109257550 hasAuthorship W2109257550A5016208813 @default.
• W2109257550 hasAuthorship W2109257550A5025518286 @default.
• W2109257550 hasAuthorship W2109257550A5032929570 @default.
• W2109257550 hasAuthorship W2109257550A5048971494 @default.
• W2109257550 hasAuthorship W2109257550A5074325380 @default.
• W2109257550 hasAuthorship W2109257550A5076045755 @default.
• W2109257550 hasAuthorship W2109257550A5087351584 @default.
• W2109257550 hasConcept C107824862 @default.
• W2109257550 hasConcept C141105273 @default.
• W2109257550 hasConcept C159654299 @default.
• W2109257550 hasConcept C170493617 @default.
• W2109257550 hasConcept C185592680 @default.
• W2109257550 hasConcept C203014093 @default.
• W2109257550 hasConcept C2779281246 @default.
• W2109257550 hasConcept C55493867 @default.
• W2109257550 hasConcept C86803240 @default.
• W2109257550 hasConceptScore W2109257550C107824862 @default.
• W2109257550 hasConceptScore W2109257550C141105273 @default.
• W2109257550 hasConceptScore W2109257550C159654299 @default.
• W2109257550 hasConceptScore W2109257550C170493617 @default.
• W2109257550 hasConceptScore W2109257550C185592680 @default.
• W2109257550 hasConceptScore W2109257550C203014093 @default.
• W2109257550 hasConceptScore W2109257550C2779281246 @default.
• W2109257550 hasConceptScore W2109257550C55493867 @default.
• W2109257550 hasConceptScore W2109257550C86803240 @default.
• W2109257550 hasIssue "16" @default.
• W2109257550 hasLocation W21092575501 @default.
• W2109257550 hasLocation W21092575502 @default.
• W2109257550 hasOpenAccess W2109257550 @default.
• W2109257550 hasPrimaryLocation W21092575501 @default.
• W2109257550 hasRelatedWork W1497168175 @default.
• W2109257550 hasRelatedWork W1594343581 @default.
• W2109257550 hasRelatedWork W1857248854 @default.
• W2109257550 hasRelatedWork W195356947 @default.

• next