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• W2109257600 startingPage "166" @default.
• W2109257600 abstract "Nasal patency shows spontaneous variations but is influenced by a number of factors like exercise and allergic conditions. Nasal histamine challenge has been used to define nasal hypersensitivity. We have applied acoustic rhinometry as a new objective method to study the spontaneous variations of the nasal mucosa and its response to histamine challenge in 12 nonallergic subjects and 12 subjects with nasal allergy to pollen, but out of the pollen season. Measurements of the minimum cross-sectional area and the volume of the nasal cavities were done every 15 min for 6 h. More pronounced spontaneous variations, defined by the coefficient of variation of the measurements, were encountered in the allergic than in the nonallergic subjects, especially with regard to the minimum cross-sectional areas in the nasal cavities (P < 0.02). Allergic subjects showed increased sensitivity to histamine, as compared with nonallergic subjects, during low-concentration (0.1%) challenge (P < 0.05) and a prolonged effect of histamine challenge (P = 0.01). Antihistamine (cetirizine) had a significant effect on the histamine-induced symptoms and decrease of nasal dimensions during histamine challenge, but no significant effect on pollen-induced changes. In the allergic group, the decrease in minimum area during allergen provocation correlated with the level of specific IgE (r = 0.81; P = 0.0015)." @default.
• W2109257600 created "2016-06-24" @default.
• W2109257600 creator A5007500813 @default.
• W2109257600 creator A5044333073 @default.
• W2109257600 creator A5046119332 @default.
• W2109257600 date "2010-08-24" @default.
• W2109257600 modified "2023-10-14" @default.
• W2109257600 title "Nasal histamine challenge in nonallergic and allergic subjects evaluated by acoustic rhinometry" @default.
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• W2109257600 doi "https://doi.org/10.1111/j.1398-9995.1995.tb05075.x" @default.
• W2109257600 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7604941" @default.
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