Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109261002> ?p ?o ?g. }
- W2109261002 endingPage "2204" @default.
- W2109261002 startingPage "2189" @default.
- W2109261002 abstract "Hepatocellular carcinoma (HCC) is the third cause of cancer-related death worldwide. Curative options for HCC are limited and exclusively available for patients carrying an early stage HCC. In advanced stages, traditional chemotherapy proved to be only marginally effective or even toxic. Thus, the identification of new treatment options is needed. New targets for non-conventional treatment will necessarily take advantage of progresses on the molecular pathogenesis of HCC. MicroRNAs (miRNAs) are a group of tiny RNAs with a fundamental role in the regulation of gene expression. Aberrant expression of several miRNAs was found to be involved in human hepatocarcinogenesis. miRNA expression signatures were correlated with bio-pathological and clinical features of HCC. In some cases, aberrantly expressed miRNAs could be linked to cancer-associated pathways, indicating a direct role in liver tumourigenesis. For example, up-regulation of mir-221 and mir-21 could promote cell cycle progression, reduce cell death and favour angiogenesis and invasion. These findings suggest that miRNAs could become novel molecular targets for HCC treatment. The demonstration of in vivo efficacy and safety of anti-miRNA compounds has opened the way to their use in clinical trials." @default.
- W2109261002 created "2016-06-24" @default.
- W2109261002 creator A5001240587 @default.
- W2109261002 creator A5010513377 @default.
- W2109261002 creator A5010972249 @default.
- W2109261002 creator A5068348071 @default.
- W2109261002 creator A5076619850 @default.
- W2109261002 creator A5079700663 @default.
- W2109261002 creator A5085011734 @default.
- W2109261002 creator A5087506952 @default.
- W2109261002 date "2008-10-13" @default.
- W2109261002 modified "2023-10-02" @default.
- W2109261002 title "MicroRNA involvement in hepatocellular carcinoma" @default.
- W2109261002 cites W1578810612 @default.
- W2109261002 cites W158070947 @default.
- W2109261002 cites W1585489139 @default.
- W2109261002 cites W1648301895 @default.
- W2109261002 cites W1823168351 @default.
- W2109261002 cites W1963691340 @default.
- W2109261002 cites W1966749076 @default.
- W2109261002 cites W1969909442 @default.
- W2109261002 cites W1971837077 @default.
- W2109261002 cites W1972345911 @default.
- W2109261002 cites W1972514043 @default.
- W2109261002 cites W1972755526 @default.
- W2109261002 cites W1972801247 @default.
- W2109261002 cites W1974303227 @default.
- W2109261002 cites W1976940986 @default.
- W2109261002 cites W1977015081 @default.
- W2109261002 cites W1979912768 @default.
- W2109261002 cites W1983109993 @default.
- W2109261002 cites W1983292214 @default.
- W2109261002 cites W1984742254 @default.
- W2109261002 cites W1984935494 @default.
- W2109261002 cites W1985324226 @default.
- W2109261002 cites W1985402095 @default.
- W2109261002 cites W1985563073 @default.
- W2109261002 cites W1987856745 @default.
- W2109261002 cites W1988045726 @default.
- W2109261002 cites W1990576890 @default.
- W2109261002 cites W1990645475 @default.
- W2109261002 cites W1992710380 @default.
- W2109261002 cites W1992712392 @default.
- W2109261002 cites W1993128964 @default.
- W2109261002 cites W1993899393 @default.
- W2109261002 cites W2000093333 @default.
- W2109261002 cites W2001761023 @default.
- W2109261002 cites W2002995168 @default.
- W2109261002 cites W2005134793 @default.
- W2109261002 cites W2006797972 @default.
- W2109261002 cites W2007601283 @default.
- W2109261002 cites W2008955962 @default.
- W2109261002 cites W2009229545 @default.
- W2109261002 cites W2010215928 @default.
- W2109261002 cites W2015018301 @default.
- W2109261002 cites W2015039463 @default.
- W2109261002 cites W2015608796 @default.
- W2109261002 cites W2020215421 @default.
- W2109261002 cites W2020830322 @default.
- W2109261002 cites W2022620076 @default.
- W2109261002 cites W2023476291 @default.
- W2109261002 cites W2023738839 @default.
- W2109261002 cites W2024199435 @default.
- W2109261002 cites W2025642178 @default.
- W2109261002 cites W2027097496 @default.
- W2109261002 cites W2027351562 @default.
- W2109261002 cites W2028945916 @default.
- W2109261002 cites W2030607381 @default.
- W2109261002 cites W2032352097 @default.
- W2109261002 cites W2032660643 @default.
- W2109261002 cites W2033150364 @default.
- W2109261002 cites W2034269086 @default.
- W2109261002 cites W2035794058 @default.
- W2109261002 cites W2036169252 @default.
- W2109261002 cites W2039164708 @default.
- W2109261002 cites W2039213901 @default.
- W2109261002 cites W2039952380 @default.
- W2109261002 cites W2042571415 @default.
- W2109261002 cites W2043649338 @default.
- W2109261002 cites W2044922611 @default.
- W2109261002 cites W2045228008 @default.
- W2109261002 cites W2050079849 @default.
- W2109261002 cites W2052235889 @default.
- W2109261002 cites W2053526872 @default.
- W2109261002 cites W2056353125 @default.
- W2109261002 cites W2059207532 @default.
- W2109261002 cites W2060981828 @default.
- W2109261002 cites W2063700716 @default.
- W2109261002 cites W2063810329 @default.
- W2109261002 cites W2066909301 @default.
- W2109261002 cites W2068825032 @default.
- W2109261002 cites W2069104846 @default.
- W2109261002 cites W2069793759 @default.
- W2109261002 cites W2069966444 @default.
- W2109261002 cites W2070396671 @default.
- W2109261002 cites W2073915650 @default.
- W2109261002 cites W2074629894 @default.
- W2109261002 cites W2076892771 @default.