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- W2109264597 abstract "The medial temporal (MT) lobes and basal ganglia have both been implicated as brain substrates of associative learning. Here, we show a dissociation between medial temporal and basal ganglia damage using a latent learning task, in which prior exposure to cues, uncorrelated with each other, slows subsequent learning of an association between them. Consistent with prior work, we found a robust exposure effect in healthy controls, with exposed controls learning more slowly than non-exposed controls. This effect was abolished in medial temporal amnesia: both exposed and non-exposed amnesic patients learned at the same speed. A group of patients with basal ganglia damage due to Parkinson’s disease showed a reversal of the effect: exposed subjects learned faster than non-exposed subjects. Our findings point to distinct and dissociable contributions of medial temporal lobe and basal ganglia structures to learning and memory." @default.
- W2109264597 created "2016-06-24" @default.
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- W2109264597 date "2003-01-01" @default.
- W2109264597 modified "2023-10-04" @default.
- W2109264597 title "Dissociating medial temporal and basal ganglia memory systems with a latent learning task" @default.
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- W2109264597 doi "https://doi.org/10.1016/s0028-3932(03)00127-1" @default.
- W2109264597 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/14572525" @default.
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