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• W2109266465 abstract "A protocol for inducing cortical spreading depression (SD) on rat neocortical slices in vitro, upon local application of calibrated ∼nl drops of KCl, 3 M was used to elicit SD events, recorded at two different points on the slice. This in vitro model was validated by the inhibition of SD episodes by the NMDA antagonist MK-801 (20 μM), the reference SD blocker. Quinine, its stereoisomer quinidine, and mefloquine consistently inhibited the SD episodes. Quinine and quinidine, 100 and 200 μM reduced the duration, while mefloquine, 100 and 200 μM reduced the amplitude of SD events, all in a concentration-dependent manner. These compounds have been reported to block gap junctions, specifically the neuronal connexin (Cx) 36, but they also exert other cellular effects. While further investigation is warranted to settle whether SD inhibition in vitro by quinine, quinidine and mefloquine reflects an involvement of neuronal Cx36 channels in SD generation/propagation, these results bear potential drug-discovery relevance for the migraine with aura." @default.
• W2109266465 created "2016-06-24" @default.
• W2109266465 creator A5018189291 @default.
• W2109266465 creator A5079291157 @default.
• W2109266465 date "2006-12-01" @default.
• W2109266465 modified "2023-10-18" @default.
• W2109266465 title "The connexin 36 blockers quinine, quinidine and mefloquine inhibit cortical spreading depression in a rat neocortical slice model in vitro" @default.
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• W2109266465 doi "https://doi.org/10.1016/j.brainresbull.2006.07.011" @default.
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