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- W2109269770 abstract "Mushrooms are food traditionally consumed in Europe, Asia and America. They are being studied for medicinal benefits. Extensive studies have shown that Agaricus subrufescens (A. blazei Murrill or A. brasiliensis) has anticancer properties. A comparative study of Agaricus subrufescens strains (from Brazil and France) is presented herein using Agaricus bisporus (champignon de Paris) as control. In vivo OCDE test were performed to evaluate either tolerance and/or acute and sub chronic toxicity in rats and mice. Our data reveal that all A. subrufescens strains are not toxic, either in vivo or in vitro, except some locomotor hypoactivity. All show a preventing effect against carcinogenesis, including A. bisporus. This is the first time that this mushroom is shown to be effective, even thought it is clearly less effective than A. subrufescens. However no anti tumour effect is found using Balb-c mice implanted with leukaemia cells. Furthermore they elicit slight cell growth stimulation at the concentrations tested in vitro, in Hep G2 (human hepatoma cells) and Neuro 2a (mouse neuroblastoma cells). The most active is A. subrufescens from Brazil. These mushrooms do have many bioactive compounds, different from the polysaccharides that need to be isolated and characterised for their curative properties following accurate evaluation of toxicological effects. Indeed there is clearly a lake of information on toxicological assessment (acute and chronic toxicity) of compound such as agaritine, blazein among others and of the whole mushroom A. subrufescens itself, and overall on epidemiological data linking the consumption of Agaricus sp and eventual prevention and/or pathologies." @default.
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- W2109269770 date "2011-10-04" @default.
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- W2109269770 title "Safety evaluation of Agaricus subrufescens varieties and their products of therarpeutic interest or for disease prevention" @default.
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