Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109276770> ?p ?o ?g. }
- W2109276770 abstract "Throughout embryonic development, macrophages not only constitute the first line of defense against infection but also help to sculpt organs and tissues of the embryo by removing dead cells and secreting extracellular matrix components. Key to their function is the ability of embryonic macrophages to migrate and disperse throughout the embryo. Yet despite these important developmental functions, little is known about the molecular mechanisms underlying embryonic macrophage migration in vivo. Integrins are key regulators of many of the adult macrophage responses, but their role in embryonic macrophages remains poorly characterized. Here, we have used Drosophila macrophages (haemocytes) as a model system to address the role of integrins during embryonic macrophage dispersal in vivo. We show that the main βPS integrin, myospheroid, affects haemocyte migration in two ways; by shaping the 3-dimensional environment in which haemocytes migrate and by regulating the migration of haemocytes themselves. Live imaging reveals a requirement for myospheroid within haemocytes for coordinating the microtubule and actin dynamics, and in enabling haemocyte developmental dispersal, contact repulsion and inflammatory migration towards wounds." @default.
- W2109276770 created "2016-06-24" @default.
- W2109276770 creator A5004157437 @default.
- W2109276770 creator A5012510463 @default.
- W2109276770 creator A5015920256 @default.
- W2109276770 creator A5042365967 @default.
- W2109276770 creator A5044868729 @default.
- W2109276770 creator A5058111655 @default.
- W2109276770 creator A5074207862 @default.
- W2109276770 creator A5083299622 @default.
- W2109276770 date "2013-01-01" @default.
- W2109276770 modified "2023-10-13" @default.
- W2109276770 title "A dual role for the βPS integrin myospheroid in mediating Drosophila embryonic macrophage migration" @default.
- W2109276770 cites W1524783912 @default.
- W2109276770 cites W1542065996 @default.
- W2109276770 cites W1576773659 @default.
- W2109276770 cites W1879685594 @default.
- W2109276770 cites W1964521956 @default.
- W2109276770 cites W1967347349 @default.
- W2109276770 cites W1968640383 @default.
- W2109276770 cites W1969397864 @default.
- W2109276770 cites W1970062316 @default.
- W2109276770 cites W1970656914 @default.
- W2109276770 cites W1982018332 @default.
- W2109276770 cites W1996137175 @default.
- W2109276770 cites W1996438523 @default.
- W2109276770 cites W2001339111 @default.
- W2109276770 cites W2013571088 @default.
- W2109276770 cites W2024631862 @default.
- W2109276770 cites W2026826181 @default.
- W2109276770 cites W2029128290 @default.
- W2109276770 cites W2030131753 @default.
- W2109276770 cites W2035538295 @default.
- W2109276770 cites W2039862938 @default.
- W2109276770 cites W2045377853 @default.
- W2109276770 cites W2052231225 @default.
- W2109276770 cites W2053080502 @default.
- W2109276770 cites W2073006837 @default.
- W2109276770 cites W2077410890 @default.
- W2109276770 cites W2086585265 @default.
- W2109276770 cites W2089169139 @default.
- W2109276770 cites W2096060868 @default.
- W2109276770 cites W2097572235 @default.
- W2109276770 cites W2097687613 @default.
- W2109276770 cites W2098120407 @default.
- W2109276770 cites W2099346304 @default.
- W2109276770 cites W2101244168 @default.
- W2109276770 cites W2108713158 @default.
- W2109276770 cites W2111778285 @default.
- W2109276770 cites W2118868562 @default.
- W2109276770 cites W2123168425 @default.
- W2109276770 cites W2129251085 @default.
- W2109276770 cites W2131283226 @default.
- W2109276770 cites W2134090916 @default.
- W2109276770 cites W2139587743 @default.
- W2109276770 cites W2141089307 @default.
- W2109276770 cites W2141932361 @default.
- W2109276770 cites W2145009320 @default.
- W2109276770 cites W2146649239 @default.
- W2109276770 cites W2146667247 @default.
- W2109276770 cites W2151476386 @default.
- W2109276770 cites W2154622534 @default.
- W2109276770 cites W2166445583 @default.
- W2109276770 cites W2241971323 @default.
- W2109276770 cites W2410820884 @default.
- W2109276770 cites W4254302635 @default.
- W2109276770 doi "https://doi.org/10.1242/jcs.129700" @default.
- W2109276770 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3730248" @default.
- W2109276770 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23704353" @default.
- W2109276770 hasPublicationYear "2013" @default.
- W2109276770 type Work @default.
- W2109276770 sameAs 2109276770 @default.
- W2109276770 citedByCount "27" @default.
- W2109276770 countsByYear W21092767702013 @default.
- W2109276770 countsByYear W21092767702014 @default.
- W2109276770 countsByYear W21092767702015 @default.
- W2109276770 countsByYear W21092767702016 @default.
- W2109276770 countsByYear W21092767702017 @default.
- W2109276770 countsByYear W21092767702018 @default.
- W2109276770 countsByYear W21092767702019 @default.
- W2109276770 countsByYear W21092767702020 @default.
- W2109276770 countsByYear W21092767702021 @default.
- W2109276770 countsByYear W21092767702022 @default.
- W2109276770 countsByYear W21092767702023 @default.
- W2109276770 crossrefType "journal-article" @default.
- W2109276770 hasAuthorship W2109276770A5004157437 @default.
- W2109276770 hasAuthorship W2109276770A5012510463 @default.
- W2109276770 hasAuthorship W2109276770A5015920256 @default.
- W2109276770 hasAuthorship W2109276770A5042365967 @default.
- W2109276770 hasAuthorship W2109276770A5044868729 @default.
- W2109276770 hasAuthorship W2109276770A5058111655 @default.
- W2109276770 hasAuthorship W2109276770A5074207862 @default.
- W2109276770 hasAuthorship W2109276770A5083299622 @default.
- W2109276770 hasBestOaLocation W21092767701 @default.
- W2109276770 hasConcept C104317684 @default.
- W2109276770 hasConcept C137738243 @default.
- W2109276770 hasConcept C145103041 @default.
- W2109276770 hasConcept C1491633281 @default.
- W2109276770 hasConcept C15526883 @default.
- W2109276770 hasConcept C189165786 @default.