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• W2109281837 startingPage "2215" @default.
• W2109281837 abstract "Wnt proteins play a crucial role in several aspects of neuronal circuit formation. Wnts can signal through different receptors including Frizzled, Ryk and Ror2. In the hippocampus, Wnt7a stimulates the formation of synapses; however, its receptor remains poorly characterized. Here, we demonstrate that Frizzled-5 (Fz5) is expressed during the peak of synaptogenesis in the mouse hippocampus. Fz5 is present in synaptosomes and colocalizes with the pre- and postsynaptic markers vGlut1 and PSD-95. Expression of Fz5 during early stages of synaptogenesis increases the number of presynaptic sites in hippocampal neurons. Conversely, Fz5 knockdown or the soluble Fz5-CRD domain (Fz5CRD), which binds to Wnt7a, block the ability of Wnt7a to stimulate synaptogenesis. Increased neuronal activity induced by K+ depolarization or by high-frequency stimulation (HFS), known to induce synapse formation, raises the levels of Fz5 at the cell surface. Importantly, both stimuli increase the localization of Fz5 at synapses, an effect that is blocked by Wnt antagonists or Fz5CRD. Conversely, low-frequency stimulation, which reduces the number of synapses, decreases the levels of surface Fz5 and the percentage of synapses containing the receptor. Interestingly, Fz5CRD abolishes HFS-induced synapse formation. Our results indicate that Fz5 mediates the synaptogenic effect of Wnt7a and that its localization to synapses is regulated by neuronal activity, a process that depends on endogenous Wnts. These findings support a model where neuronal activity and Wnts increase the responsiveness of neurons to Wnt signalling by recruiting Fz5 receptor at synaptic sites." @default.
• W2109281837 created "2016-06-24" @default.
• W2109281837 creator A5020195440 @default.
• W2109281837 creator A5023045140 @default.
• W2109281837 creator A5048836076 @default.
• W2109281837 date "2010-07-01" @default.
• W2109281837 modified "2023-10-18" @default.
• W2109281837 title "Frizzled-5, a receptor for the synaptic organizer Wnt7a, regulates activity-mediated synaptogenesis" @default.
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• W2109281837 cites W1979586675 @default.
• W2109281837 cites W1983699648 @default.
• W2109281837 cites W1985241009 @default.
• W2109281837 cites W1986408320 @default.
• W2109281837 cites W1986512833 @default.
• W2109281837 cites W1989184804 @default.
• W2109281837 cites W1996553105 @default.
• W2109281837 cites W1997467265 @default.
• W2109281837 cites W1998977808 @default.
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• W2109281837 cites W2021747430 @default.
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• W2109281837 cites W2053850015 @default.
• W2109281837 cites W2054207274 @default.
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• W2109281837 doi "https://doi.org/10.1242/dev.046722" @default.
• W2109281837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2882138" @default.
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• W2109281837 hasPublicationYear "2010" @default.
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