FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109288527> ?p ?o ?g. }

• W2109288527 endingPage "1925" @default.
• W2109288527 startingPage "1917" @default.
• W2109288527 abstract "OBJECTIVE Comprehensive proteomic profiling of the human adipocyte secretome identified dipeptidyl peptidase 4 (DPP4) as a novel adipokine. This study assessed the functional implications of the adipokine DPP4 and its association to the metabolic syndrome. RESEARCH DESIGN AND METHODS Human adipocytes and skeletal and smooth muscle cells were used to monitor DPP4 release and assess the effects of soluble DPP4 on insulin signaling. In lean and obese subjects, depot-specific expression of DPP4 and its release from adipose tissue explants were determined and correlated to parameters of the metabolic syndrome. RESULTS Fully differentiated adipocytes exhibit a substantially higher release of DPP4 compared with preadipocytes or macrophages. Direct addition of DPP4 to fat and skeletal and smooth muscle cells impairs insulin signaling. A fivefold higher level of DPP4 protein expression was seen in visceral compared with subcutaneous fat of obese patients, with no regional difference in lean subjects. DPP4 serum concentrations significantly correlated with adipocyte size. By using adipose tissue explants from lean and obese subjects, we observed a twofold increase in DPP4 release that strongly correlated with adipocyte volume and parameters of the metabolic syndrome and was decreased to the lean level after weight reduction. DPP4 released from adipose tissue correlated positively with an increasing risk score for the metabolic syndrome. CONCLUSIONS DPP4 is a novel adipokine that may impair insulin sensitivity in an autocrine and paracrine fashion. Furthermore, DPP4 release strongly correlates with adipocyte size, potentially representing an important source of DPP4 in obesity. Therefore, we suggest that DPP4 may be involved in linking adipose tissue and the metabolic syndrome." @default.
• W2109288527 created "2016-06-24" @default.
• W2109288527 creator A5010357562 @default.
• W2109288527 creator A5014563036 @default.
• W2109288527 creator A5020607761 @default.
• W2109288527 creator A5023333861 @default.
• W2109288527 creator A5025732053 @default.
• W2109288527 creator A5029349104 @default.
• W2109288527 creator A5031431980 @default.
• W2109288527 creator A5031934048 @default.
• W2109288527 creator A5031987417 @default.
• W2109288527 creator A5035921730 @default.
• W2109288527 creator A5038112028 @default.
• W2109288527 creator A5045227835 @default.
• W2109288527 creator A5049835759 @default.
• W2109288527 creator A5064793416 @default.
• W2109288527 creator A5064986157 @default.
• W2109288527 date "2011-06-20" @default.
• W2109288527 modified "2023-10-18" @default.
• W2109288527 title "Dipeptidyl Peptidase 4 Is a Novel Adipokine Potentially Linking Obesity to the Metabolic Syndrome" @default.
• W2109288527 cites W1567505077 @default.
• W2109288527 cites W1940950287 @default.
• W2109288527 cites W1975726794 @default.
• W2109288527 cites W1980225051 @default.
• W2109288527 cites W1982624540 @default.
• W2109288527 cites W1987621836 @default.
• W2109288527 cites W1988109900 @default.
• W2109288527 cites W2008325392 @default.
• W2109288527 cites W2010603227 @default.
• W2109288527 cites W2028849170 @default.
• W2109288527 cites W2030549041 @default.
• W2109288527 cites W2031468509 @default.
• W2109288527 cites W2032322539 @default.
• W2109288527 cites W2038686627 @default.
• W2109288527 cites W2039934598 @default.
• W2109288527 cites W2056573366 @default.
• W2109288527 cites W2064119981 @default.
• W2109288527 cites W2069229112 @default.
• W2109288527 cites W2071601558 @default.
• W2109288527 cites W2092422666 @default.
• W2109288527 cites W2104391911 @default.
• W2109288527 cites W2106919150 @default.
• W2109288527 cites W2132537556 @default.
• W2109288527 cites W2134141467 @default.
• W2109288527 cites W2142852356 @default.
• W2109288527 cites W2155952279 @default.
• W2109288527 cites W2159205789 @default.
• W2109288527 cites W2162768091 @default.
• W2109288527 cites W2167522349 @default.
• W2109288527 cites W2487142160 @default.
• W2109288527 doi "https://doi.org/10.2337/db10-1707" @default.
• W2109288527 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3121429" @default.
• W2109288527 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21593202" @default.
• W2109288527 hasPublicationYear "2011" @default.
• W2109288527 type Work @default.
• W2109288527 sameAs 2109288527 @default.
• W2109288527 citedByCount "492" @default.
• W2109288527 countsByYear W21092885272012 @default.
• W2109288527 countsByYear W21092885272013 @default.
• W2109288527 countsByYear W21092885272014 @default.
• W2109288527 countsByYear W21092885272015 @default.
• W2109288527 countsByYear W21092885272016 @default.
• W2109288527 countsByYear W21092885272017 @default.
• W2109288527 countsByYear W21092885272018 @default.
• W2109288527 countsByYear W21092885272019 @default.
• W2109288527 countsByYear W21092885272020 @default.
• W2109288527 countsByYear W21092885272021 @default.
• W2109288527 countsByYear W21092885272022 @default.
• W2109288527 countsByYear W21092885272023 @default.
• W2109288527 crossrefType "journal-article" @default.
• W2109288527 hasAuthorship W2109288527A5010357562 @default.
• W2109288527 hasAuthorship W2109288527A5014563036 @default.
• W2109288527 hasAuthorship W2109288527A5020607761 @default.
• W2109288527 hasAuthorship W2109288527A5023333861 @default.
• W2109288527 hasAuthorship W2109288527A5025732053 @default.
• W2109288527 hasAuthorship W2109288527A5029349104 @default.
• W2109288527 hasAuthorship W2109288527A5031431980 @default.
• W2109288527 hasAuthorship W2109288527A5031934048 @default.
• W2109288527 hasAuthorship W2109288527A5031987417 @default.
• W2109288527 hasAuthorship W2109288527A5035921730 @default.
• W2109288527 hasAuthorship W2109288527A5038112028 @default.
• W2109288527 hasAuthorship W2109288527A5045227835 @default.
• W2109288527 hasAuthorship W2109288527A5049835759 @default.
• W2109288527 hasAuthorship W2109288527A5064793416 @default.
• W2109288527 hasAuthorship W2109288527A5064986157 @default.
• W2109288527 hasBestOaLocation W21092885271 @default.
• W2109288527 hasConcept C126322002 @default.
• W2109288527 hasConcept C134018914 @default.
• W2109288527 hasConcept C156490143 @default.
• W2109288527 hasConcept C170493617 @default.
• W2109288527 hasConcept C171089720 @default.
• W2109288527 hasConcept C194832188 @default.
• W2109288527 hasConcept C2776175234 @default.
• W2109288527 hasConcept C2777180221 @default.
• W2109288527 hasConcept C2777391703 @default.
• W2109288527 hasConcept C2779306644 @default.
• W2109288527 hasConcept C2780578515 @default.
• W2109288527 hasConcept C511355011 @default.

• next