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- W2109291283 abstract "Abstract Background: Wound contraction and scar formation in the palatal mucoperiosteum after cleft palate surgery impair maxillary growth. The aim of this study was to determine the effects of IFN‐β on palatal mucoperiosteal wound healing in growing rats. Methods: Standardized wounds were made in the palatal mucoperiosteum of young rats. Either IFN‐β or vehicle were injected at the wound site between 4 and 29 days after wounding. The results were compared with control wounds. Tissue samples were collected at 8, 15, 30, and 60 days PW for biochemical and microscopic analysis. Results: IFN‐β stimulated re‐epithelialization but did not reduce the number of myofibroblasts or scar tissue formation. Surprisingly, the injection of vehicle alone delayed the healing process. Conclusion: IFN‐β might be suitable to stimulate re‐epithelialization but it does not reduce scar tissue formation in rat palatal wound healing. The injection of agents into palatal wounds might severely impair the healing process." @default.
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- W2109291283 date "2002-09-19" @default.
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- W2109291283 title "Effects of locally injected interferon-β on palatal mucoperiosteal wound healing" @default.
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- W2109291283 doi "https://doi.org/10.1034/j.1600-0714.2002.00026.x" @default.
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