Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109303312> ?p ?o ?g. }
- W2109303312 abstract "Over the past decade, genome-scale metabolic models have gained widespread acceptance in biology and bioengineering as a means of quantitatively predicting organism behavior based on the stoichiometry of the biochemical reactions constituting the organism metabolism. The list of applications for these models is rapidly growing; they have been used to identify essential genes, determine growth conditions, predict phenotypes, predict response to mutation, and study the impact of transcriptional regulation on organism phenotypes. This growing field of applications, combined with the rapidly growing number of available genome- scale models, is producing a significant demand for computation to analyze these models. Here we discuss how high-performance computing may be applied with various algorithms for the reconstruction, analysis, and optimization of genome-scale metabolic models. We also performed a case study to demonstrate how the algorithm for simulating gene knockouts scales when run on up to 65,536 processors on Blue Gene/P. In this case study, the knockout of every possible combination of one, two, three, and four genes was simulated in the iBsu1103 genome-scale model of B. subtilis. In 162 minutes, 18,243,776,054 knockouts were simulated on 65,536 processors, revealing 288 essential single knockouts, 78 essential double knockouts, 99 essential triple knockouts, and only 28 essential quadruple knockouts." @default.
- W2109303312 created "2016-06-24" @default.
- W2109303312 creator A5017949757 @default.
- W2109303312 creator A5049471852 @default.
- W2109303312 creator A5053682943 @default.
- W2109303312 date "2009-07-01" @default.
- W2109303312 modified "2023-09-26" @default.
- W2109303312 title "Application of high-performance computing to the reconstruction, analysis, and optimization of genome-scale metabolic models" @default.
- W2109303312 cites W1597762351 @default.
- W2109303312 cites W1797657318 @default.
- W2109303312 cites W1928728086 @default.
- W2109303312 cites W1966614672 @default.
- W2109303312 cites W1969253588 @default.
- W2109303312 cites W1982440567 @default.
- W2109303312 cites W1983120620 @default.
- W2109303312 cites W1986656046 @default.
- W2109303312 cites W1986919009 @default.
- W2109303312 cites W2004548026 @default.
- W2109303312 cites W2019631913 @default.
- W2109303312 cites W2026054660 @default.
- W2109303312 cites W2042067428 @default.
- W2109303312 cites W2042938763 @default.
- W2109303312 cites W2049814691 @default.
- W2109303312 cites W2072013780 @default.
- W2109303312 cites W2073837631 @default.
- W2109303312 cites W2076262841 @default.
- W2109303312 cites W2086016524 @default.
- W2109303312 cites W2107409961 @default.
- W2109303312 cites W2120353169 @default.
- W2109303312 cites W2126175129 @default.
- W2109303312 cites W2128746754 @default.
- W2109303312 cites W2130364940 @default.
- W2109303312 cites W2143861551 @default.
- W2109303312 cites W2153373497 @default.
- W2109303312 doi "https://doi.org/10.1088/1742-6596/180/1/012025" @default.
- W2109303312 hasPublicationYear "2009" @default.
- W2109303312 type Work @default.
- W2109303312 sameAs 2109303312 @default.
- W2109303312 citedByCount "11" @default.
- W2109303312 countsByYear W21093033122012 @default.
- W2109303312 countsByYear W21093033122013 @default.
- W2109303312 countsByYear W21093033122015 @default.
- W2109303312 countsByYear W21093033122017 @default.
- W2109303312 crossrefType "journal-article" @default.
- W2109303312 hasAuthorship W2109303312A5017949757 @default.
- W2109303312 hasAuthorship W2109303312A5049471852 @default.
- W2109303312 hasAuthorship W2109303312A5053682943 @default.
- W2109303312 hasBestOaLocation W21093033121 @default.
- W2109303312 hasConcept C104317684 @default.
- W2109303312 hasConcept C121332964 @default.
- W2109303312 hasConcept C137858568 @default.
- W2109303312 hasConcept C141231307 @default.
- W2109303312 hasConcept C152662350 @default.
- W2109303312 hasConcept C177264268 @default.
- W2109303312 hasConcept C189206191 @default.
- W2109303312 hasConcept C19843653 @default.
- W2109303312 hasConcept C199360897 @default.
- W2109303312 hasConcept C2778755073 @default.
- W2109303312 hasConcept C41008148 @default.
- W2109303312 hasConcept C54355233 @default.
- W2109303312 hasConcept C62520636 @default.
- W2109303312 hasConcept C70721500 @default.
- W2109303312 hasConcept C77957584 @default.
- W2109303312 hasConcept C86803240 @default.
- W2109303312 hasConceptScore W2109303312C104317684 @default.
- W2109303312 hasConceptScore W2109303312C121332964 @default.
- W2109303312 hasConceptScore W2109303312C137858568 @default.
- W2109303312 hasConceptScore W2109303312C141231307 @default.
- W2109303312 hasConceptScore W2109303312C152662350 @default.
- W2109303312 hasConceptScore W2109303312C177264268 @default.
- W2109303312 hasConceptScore W2109303312C189206191 @default.
- W2109303312 hasConceptScore W2109303312C19843653 @default.
- W2109303312 hasConceptScore W2109303312C199360897 @default.
- W2109303312 hasConceptScore W2109303312C2778755073 @default.
- W2109303312 hasConceptScore W2109303312C41008148 @default.
- W2109303312 hasConceptScore W2109303312C54355233 @default.
- W2109303312 hasConceptScore W2109303312C62520636 @default.
- W2109303312 hasConceptScore W2109303312C70721500 @default.
- W2109303312 hasConceptScore W2109303312C77957584 @default.
- W2109303312 hasConceptScore W2109303312C86803240 @default.
- W2109303312 hasLocation W21093033121 @default.
- W2109303312 hasOpenAccess W2109303312 @default.
- W2109303312 hasPrimaryLocation W21093033121 @default.
- W2109303312 hasRelatedWork W1998633945 @default.
- W2109303312 hasRelatedWork W2031010225 @default.
- W2109303312 hasRelatedWork W2100084634 @default.
- W2109303312 hasRelatedWork W2100478279 @default.
- W2109303312 hasRelatedWork W2109636601 @default.
- W2109303312 hasRelatedWork W2126175129 @default.
- W2109303312 hasRelatedWork W2134900891 @default.
- W2109303312 hasRelatedWork W2147472054 @default.
- W2109303312 hasRelatedWork W2170427655 @default.
- W2109303312 hasRelatedWork W2171229431 @default.
- W2109303312 hasRelatedWork W2261694759 @default.
- W2109303312 hasRelatedWork W2409535058 @default.
- W2109303312 hasRelatedWork W2583606901 @default.
- W2109303312 hasRelatedWork W2781174748 @default.
- W2109303312 hasRelatedWork W2921101297 @default.
- W2109303312 hasRelatedWork W2941357190 @default.
- W2109303312 hasRelatedWork W2949144734 @default.