Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109307504> ?p ?o ?g. }
- W2109307504 endingPage "299" @default.
- W2109307504 startingPage "288" @default.
- W2109307504 abstract "Atherosclerosis is a lipid-driven inflammatory disease of the vessel wall, characterized by the chronic activation of macrophages. We investigated whether the helminth-derived antigens [soluble egg antigens (SEAs)] could modulate macrophage inflammatory responses and protect against atherosclerosis in mice. In bone marrow-derived macrophages, SEAs induce anti-inflammatory macrophages, typified by high levels of IL-10 and reduced secretion of proinflammatory mediators. In hyperlipidemic LDLR(-/-) mice, SEA treatment reduced plaque size by 44%, and plaques were less advanced compared with PBS-injected littermate controls. The atheroprotective effect of SEAs was found to be mainly independent of cholesterol lowering and T-lymphocyte responses but instead could be attributed to diminished myeloid cell activation. SEAs reduced circulating neutrophils and inflammatory Ly6C(high) monocytes, and macrophages showed high IL-10 production. In line with the observed systemic effects, atherosclerotic lesions of SEA-treated mice showed reduced intraplaque inflammation as inflammatory markers [TNF-α, monocyte chemotactic protein 1 (MCP-1), intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and CD68], neutrophil content, and newly recruited macrophages were decreased. We show that SEA treatment protects against atherosclerosis development by dampening inflammatory responses. In the future, helminth-derived components may provide novel opportunities to treat chronic inflammatory diseases, as they diminish systemic inflammation and reduce the activation of immune cells." @default.
- W2109307504 created "2016-06-24" @default.
- W2109307504 creator A5002563142 @default.
- W2109307504 creator A5020668415 @default.
- W2109307504 creator A5025368031 @default.
- W2109307504 creator A5032727410 @default.
- W2109307504 creator A5049396254 @default.
- W2109307504 creator A5049641098 @default.
- W2109307504 creator A5050932373 @default.
- W2109307504 creator A5058493212 @default.
- W2109307504 creator A5065699765 @default.
- W2109307504 creator A5076844064 @default.
- W2109307504 creator A5078175367 @default.
- W2109307504 creator A5080953563 @default.
- W2109307504 creator A5081788574 @default.
- W2109307504 creator A5082105014 @default.
- W2109307504 creator A5088334780 @default.
- W2109307504 date "2013-09-16" @default.
- W2109307504 modified "2023-09-27" @default.
- W2109307504 title "Reprogramming macrophages to an anti‐inflammatory phenotype by helminth antigens reduces murine atherosclerosis" @default.
- W2109307504 cites W1665471078 @default.
- W2109307504 cites W1767092522 @default.
- W2109307504 cites W1950874980 @default.
- W2109307504 cites W1965366343 @default.
- W2109307504 cites W1966375908 @default.
- W2109307504 cites W1973648078 @default.
- W2109307504 cites W1979151464 @default.
- W2109307504 cites W1979413298 @default.
- W2109307504 cites W1986109976 @default.
- W2109307504 cites W1988128973 @default.
- W2109307504 cites W1990504071 @default.
- W2109307504 cites W1993390629 @default.
- W2109307504 cites W2008960002 @default.
- W2109307504 cites W2016451329 @default.
- W2109307504 cites W2016554818 @default.
- W2109307504 cites W2016559204 @default.
- W2109307504 cites W2017176563 @default.
- W2109307504 cites W2020744745 @default.
- W2109307504 cites W2022322779 @default.
- W2109307504 cites W2035817205 @default.
- W2109307504 cites W2041352234 @default.
- W2109307504 cites W2042854425 @default.
- W2109307504 cites W2052472267 @default.
- W2109307504 cites W2052554962 @default.
- W2109307504 cites W2057835664 @default.
- W2109307504 cites W2062997740 @default.
- W2109307504 cites W2064255959 @default.
- W2109307504 cites W2064890454 @default.
- W2109307504 cites W2065902165 @default.
- W2109307504 cites W2069474631 @default.
- W2109307504 cites W2070855360 @default.
- W2109307504 cites W2073283130 @default.
- W2109307504 cites W2073958483 @default.
- W2109307504 cites W2080326405 @default.
- W2109307504 cites W2091557419 @default.
- W2109307504 cites W2091664929 @default.
- W2109307504 cites W2095830300 @default.
- W2109307504 cites W2098251798 @default.
- W2109307504 cites W2103913523 @default.
- W2109307504 cites W2106011334 @default.
- W2109307504 cites W2107820726 @default.
- W2109307504 cites W2108975697 @default.
- W2109307504 cites W2119691919 @default.
- W2109307504 cites W2122522635 @default.
- W2109307504 cites W2129189963 @default.
- W2109307504 cites W2134433534 @default.
- W2109307504 cites W2144812374 @default.
- W2109307504 cites W2147326548 @default.
- W2109307504 cites W2155370249 @default.
- W2109307504 cites W2158380859 @default.
- W2109307504 cites W2159315975 @default.
- W2109307504 cites W2166118660 @default.
- W2109307504 cites W2316275277 @default.
- W2109307504 cites W2780661842 @default.
- W2109307504 doi "https://doi.org/10.1096/fj.13-235911" @default.
- W2109307504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24043262" @default.
- W2109307504 hasPublicationYear "2013" @default.
- W2109307504 type Work @default.
- W2109307504 sameAs 2109307504 @default.
- W2109307504 citedByCount "69" @default.
- W2109307504 countsByYear W21093075042014 @default.
- W2109307504 countsByYear W21093075042015 @default.
- W2109307504 countsByYear W21093075042016 @default.
- W2109307504 countsByYear W21093075042017 @default.
- W2109307504 countsByYear W21093075042018 @default.
- W2109307504 countsByYear W21093075042019 @default.
- W2109307504 countsByYear W21093075042020 @default.
- W2109307504 countsByYear W21093075042021 @default.
- W2109307504 countsByYear W21093075042022 @default.
- W2109307504 countsByYear W21093075042023 @default.
- W2109307504 crossrefType "journal-article" @default.
- W2109307504 hasAuthorship W2109307504A5002563142 @default.
- W2109307504 hasAuthorship W2109307504A5020668415 @default.
- W2109307504 hasAuthorship W2109307504A5025368031 @default.
- W2109307504 hasAuthorship W2109307504A5032727410 @default.
- W2109307504 hasAuthorship W2109307504A5049396254 @default.
- W2109307504 hasAuthorship W2109307504A5049641098 @default.
- W2109307504 hasAuthorship W2109307504A5050932373 @default.