Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109311551> ?p ?o ?g. }
- W2109311551 abstract "For more than a decade, flow cytometry-based automated haematology analysers have been studied for malaria diagnosis. Although current haematology analysers are not specifically designed to detect malaria-related abnormalities, most studies have found sensitivities that comply with WHO malaria-diagnostic guidelines, i.e. ≥ 95% in samples with > 100 parasites/μl. Establishing a correct and early malaria diagnosis is a prerequisite for an adequate treatment and to minimizing adverse outcomes. Expert light microscopy remains the 'gold standard' for malaria diagnosis in most clinical settings. However, it requires an explicit request from clinicians and has variable accuracy. Malaria diagnosis with flow cytometry-based haematology analysers could become an important adjuvant diagnostic tool in the routine laboratory work-up of febrile patients in or returning from malaria-endemic regions. Haematology analysers so far studied for malaria diagnosis are the Cell-Dyn®, Coulter® GEN·S and LH 750, and the Sysmex XE-2100® analysers. For Cell-Dyn analysers, abnormal depolarization events mainly in the lobularity/granularity and other scatter-plots, and various reticulocyte abnormalities have shown overall sensitivities and specificities of 49% to 97% and 61% to 100%, respectively. For the Coulter analysers, a 'malaria factor' using the monocyte and lymphocyte size standard deviations obtained by impedance detection has shown overall sensitivities and specificities of 82% to 98% and 72% to 94%, respectively. For the XE-2100, abnormal patterns in the DIFF, WBC/BASO, and RET-EXT scatter-plots, and pseudoeosinophilia and other abnormal haematological variables have been described, and multivariate diagnostic models have been designed with overall sensitivities and specificities of 86% to 97% and 81% to 98%, respectively. The accuracy for malaria diagnosis may vary according to species, parasite load, immunity and clinical context where the method is applied. Future developments in new haematology analysers such as considerably simplified, robust and inexpensive devices for malaria detection fitted with an automatically generated alert could improve the detection capacity of these instruments and potentially expand their clinical utility in malaria diagnosis." @default.
- W2109311551 created "2016-06-24" @default.
- W2109311551 creator A5020576056 @default.
- W2109311551 creator A5057033264 @default.
- W2109311551 creator A5087477162 @default.
- W2109311551 date "2010-11-30" @default.
- W2109311551 modified "2023-10-12" @default.
- W2109311551 title "Automated haematology analysis to diagnose malaria" @default.
- W2109311551 cites W1474773865 @default.
- W2109311551 cites W1901229421 @default.
- W2109311551 cites W1966469029 @default.
- W2109311551 cites W1968010484 @default.
- W2109311551 cites W1971871685 @default.
- W2109311551 cites W1977428119 @default.
- W2109311551 cites W1979841259 @default.
- W2109311551 cites W1981153667 @default.
- W2109311551 cites W1983747538 @default.
- W2109311551 cites W1987261013 @default.
- W2109311551 cites W1987267163 @default.
- W2109311551 cites W1988963999 @default.
- W2109311551 cites W1994938904 @default.
- W2109311551 cites W2003741250 @default.
- W2109311551 cites W2013580924 @default.
- W2109311551 cites W2015772567 @default.
- W2109311551 cites W2030163534 @default.
- W2109311551 cites W2032048538 @default.
- W2109311551 cites W2032173237 @default.
- W2109311551 cites W2035077599 @default.
- W2109311551 cites W2044539327 @default.
- W2109311551 cites W2045644690 @default.
- W2109311551 cites W2047945425 @default.
- W2109311551 cites W2049893845 @default.
- W2109311551 cites W2051078119 @default.
- W2109311551 cites W2054049765 @default.
- W2109311551 cites W2054811219 @default.
- W2109311551 cites W2059787091 @default.
- W2109311551 cites W2068278921 @default.
- W2109311551 cites W2069053912 @default.
- W2109311551 cites W2069122745 @default.
- W2109311551 cites W2102689314 @default.
- W2109311551 cites W2105872886 @default.
- W2109311551 cites W2112222752 @default.
- W2109311551 cites W2115837962 @default.
- W2109311551 cites W2115855731 @default.
- W2109311551 cites W2121008423 @default.
- W2109311551 cites W2132611974 @default.
- W2109311551 cites W2137615559 @default.
- W2109311551 cites W2142035905 @default.
- W2109311551 cites W2144471978 @default.
- W2109311551 cites W2154482991 @default.
- W2109311551 cites W2155386647 @default.
- W2109311551 cites W2164706536 @default.
- W2109311551 cites W2169506054 @default.
- W2109311551 cites W2476651486 @default.
- W2109311551 cites W4205620444 @default.
- W2109311551 cites W88566818 @default.
- W2109311551 cites W2036428374 @default.
- W2109311551 doi "https://doi.org/10.1186/1475-2875-9-346" @default.
- W2109311551 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3013084" @default.
- W2109311551 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21118557" @default.
- W2109311551 hasPublicationYear "2010" @default.
- W2109311551 type Work @default.
- W2109311551 sameAs 2109311551 @default.
- W2109311551 citedByCount "42" @default.
- W2109311551 countsByYear W21093115512012 @default.
- W2109311551 countsByYear W21093115512013 @default.
- W2109311551 countsByYear W21093115512014 @default.
- W2109311551 countsByYear W21093115512015 @default.
- W2109311551 countsByYear W21093115512016 @default.
- W2109311551 countsByYear W21093115512017 @default.
- W2109311551 countsByYear W21093115512018 @default.
- W2109311551 countsByYear W21093115512019 @default.
- W2109311551 countsByYear W21093115512020 @default.
- W2109311551 countsByYear W21093115512021 @default.
- W2109311551 countsByYear W21093115512022 @default.
- W2109311551 countsByYear W21093115512023 @default.
- W2109311551 crossrefType "journal-article" @default.
- W2109311551 hasAuthorship W2109311551A5020576056 @default.
- W2109311551 hasAuthorship W2109311551A5057033264 @default.
- W2109311551 hasAuthorship W2109311551A5087477162 @default.
- W2109311551 hasBestOaLocation W21093115511 @default.
- W2109311551 hasConcept C126322002 @default.
- W2109311551 hasConcept C142724271 @default.
- W2109311551 hasConcept C194409129 @default.
- W2109311551 hasConcept C203014093 @default.
- W2109311551 hasConcept C2778048844 @default.
- W2109311551 hasConcept C2780339063 @default.
- W2109311551 hasConcept C2993758460 @default.
- W2109311551 hasConcept C40993552 @default.
- W2109311551 hasConcept C553184892 @default.
- W2109311551 hasConcept C71924100 @default.
- W2109311551 hasConceptScore W2109311551C126322002 @default.
- W2109311551 hasConceptScore W2109311551C142724271 @default.
- W2109311551 hasConceptScore W2109311551C194409129 @default.
- W2109311551 hasConceptScore W2109311551C203014093 @default.
- W2109311551 hasConceptScore W2109311551C2778048844 @default.
- W2109311551 hasConceptScore W2109311551C2780339063 @default.
- W2109311551 hasConceptScore W2109311551C2993758460 @default.
- W2109311551 hasConceptScore W2109311551C40993552 @default.
- W2109311551 hasConceptScore W2109311551C553184892 @default.