FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109311906> ?p ?o ?g. }

• W2109311906 endingPage "4" @default.
• W2109311906 startingPage "2891" @default.
• W2109311906 abstract "O6-Benzylguanine (O6BG) irreversibly inactivates the single-turnover DNA repair protein alkylguanine-alkyltransferase. Thus, O6BG increases tumor-cell sensitivity to alkylating agents such as carmustine, lomustine, procarbazine, and temozolomide. We investigated the pharmacokinetic behavior of O6BG and O6-benzyl-8-oxoguanine (8-oxo-O6BG) in cerebrospinal fluid (CSF) and plasma after intraventricular administration of O6BG in a nonhuman primate model. In our study, three animals received a single 1-mg dose of O6BG into the lateral ventricle. CSF from the 4th ventricle and plasma samples were collected after administration, and O6BG and 8-oxo-O6BG concentrations were measured by high-performance liquid chromatography. Four additional animals received 1 mg of O6BG via the intralumbar route weekly for 6 weeks to assess the feasibility and toxicity of this route of administration. The peak O6BG CSF concentration was 412+/-86 microM, the t1/2 was 0.52+/-0.02 h, the clearance was 0.22+/-0.01 ml/min, and the area under the concentration-time curve was 319+/-15 microM x h in 4th ventricular CSF. The peak CSF concentration of 8-oxo-O6BG in CSF was 1.9+/-0.4 microM, the t1/2 was 0.76+/-0.03 h, and the area under the concentration-time curve was 5.0+/-1.1 microM x h. Both O6BG and 8-oxo-O6BG were detected in the plasma 0.5-3 h after intraventricular O6BG administration. The plasma peak concentration of O6BG was 0.4 microM at 30 min, and the concentration was <0.1 microM by 3 h. The plasma concentration of 8-oxo-O6BG was 0.2 microM at 30 min and 0.6 microM at 3 h. The animals tolerated the single intraventricular dose and 6 weekly intralumbar doses of O6BG without toxicity. We concluded that intrathecal administration of O6BG is well tolerated in the nonhuman primate and seems to have a substantial pharmacokinetic advantage over systemic administration for meningeal tumors." @default.
• W2109311906 created "2016-06-24" @default.
• W2109311906 creator A5024249524 @default.
• W2109311906 creator A5034404939 @default.
• W2109311906 creator A5078484599 @default.
• W2109311906 creator A5082380296 @default.
• W2109311906 creator A5086232759 @default.
• W2109311906 date "1998-11-01" @default.
• W2109311906 modified "2023-09-23" @default.
• W2109311906 title "Pharmacokinetics of O6-benzylguanine and its active metabolite 8-oxo-O6-benzylguanine in plasma and cerebrospinal fluid after intrathecal administration of O6-benzylguanine in the nonhuman primate." @default.
• W2109311906 cites W1537425172 @default.
• W2109311906 cites W1563201163 @default.
• W2109311906 cites W2042021080 @default.
• W2109311906 cites W2048397306 @default.
• W2109311906 cites W2050321855 @default.
• W2109311906 cites W2059888592 @default.
• W2109311906 cites W2100843222 @default.
• W2109311906 cites W2111960505 @default.
• W2109311906 cites W2115938423 @default.
• W2109311906 cites W2153241484 @default.
• W2109311906 cites W2193745126 @default.
• W2109311906 cites W2406581674 @default.
• W2109311906 cites W2409186476 @default.
• W2109311906 cites W2464463623 @default.
• W2109311906 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9829757" @default.
• W2109311906 hasPublicationYear "1998" @default.
• W2109311906 type Work @default.
• W2109311906 sameAs 2109311906 @default.
• W2109311906 citedByCount "2" @default.
• W2109311906 crossrefType "journal-article" @default.
• W2109311906 hasAuthorship W2109311906A5024249524 @default.
• W2109311906 hasAuthorship W2109311906A5034404939 @default.
• W2109311906 hasAuthorship W2109311906A5078484599 @default.
• W2109311906 hasAuthorship W2109311906A5082380296 @default.
• W2109311906 hasAuthorship W2109311906A5086232759 @default.
• W2109311906 hasConcept C112705442 @default.
• W2109311906 hasConcept C126322002 @default.
• W2109311906 hasConcept C149151106 @default.
• W2109311906 hasConcept C185592680 @default.
• W2109311906 hasConcept C2776694085 @default.
• W2109311906 hasConcept C2777477808 @default.
• W2109311906 hasConcept C2778119113 @default.
• W2109311906 hasConcept C2779651940 @default.
• W2109311906 hasConcept C2780147359 @default.
• W2109311906 hasConcept C55493867 @default.
• W2109311906 hasConcept C71924100 @default.
• W2109311906 hasConcept C98274493 @default.
• W2109311906 hasConceptScore W2109311906C112705442 @default.
• W2109311906 hasConceptScore W2109311906C126322002 @default.
• W2109311906 hasConceptScore W2109311906C149151106 @default.
• W2109311906 hasConceptScore W2109311906C185592680 @default.
• W2109311906 hasConceptScore W2109311906C2776694085 @default.
• W2109311906 hasConceptScore W2109311906C2777477808 @default.
• W2109311906 hasConceptScore W2109311906C2778119113 @default.
• W2109311906 hasConceptScore W2109311906C2779651940 @default.
• W2109311906 hasConceptScore W2109311906C2780147359 @default.
• W2109311906 hasConceptScore W2109311906C55493867 @default.
• W2109311906 hasConceptScore W2109311906C71924100 @default.
• W2109311906 hasConceptScore W2109311906C98274493 @default.
• W2109311906 hasIssue "11" @default.
• W2109311906 hasLocation W21093119061 @default.
• W2109311906 hasOpenAccess W2109311906 @default.
• W2109311906 hasPrimaryLocation W21093119061 @default.
• W2109311906 hasRelatedWork W1870968175 @default.
• W2109311906 hasRelatedWork W1964759623 @default.
• W2109311906 hasRelatedWork W1997401353 @default.
• W2109311906 hasRelatedWork W1998356222 @default.
• W2109311906 hasRelatedWork W2007079254 @default.
• W2109311906 hasRelatedWork W2018753489 @default.
• W2109311906 hasRelatedWork W2081460129 @default.
• W2109311906 hasRelatedWork W2132691174 @default.
• W2109311906 hasRelatedWork W2167270482 @default.
• W2109311906 hasRelatedWork W2900112275 @default.
• W2109311906 hasVolume "4" @default.
• W2109311906 isParatext "false" @default.
• W2109311906 isRetracted "false" @default.
• W2109311906 magId "2109311906" @default.
• W2109311906 workType "article" @default.