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• W2109323414 endingPage "1265" @default.
• W2109323414 startingPage "1257" @default.
• W2109323414 abstract "Mutations in mitochondrial DNA (mtDNA) cause a variety of relatively rare human diseases and may contribute to the pathogenesis of other, more common degenerative diseases. This stimulates interest in the capacity of mitochondria to repair damage to mtDNA. Several recent studies have shown that some types of damage to mtDNA may be repaired, particularly if the lesions can be processed through a base excision mechanism that employs an abasic site as a common intermediate. In this paper, we demonstrate that a combination of enzymes purified from Xenopus laevis mitochondria efficiently repairs abasic sites in DNA. This repair pathway employs a mitochondrial class II apurinic/apyrimidinic (AP) endonuclease to cleave the DNA backbone on the 5′ side of an abasic site. A deoxyribophosphodiesterase acts to remove the 5′ sugar-phosphate residue left by AP endonuclease. mtDNA polymerase γ fills the resulting 1-nucleotide gap. The remaining nick is sealed by an mtDNA ligase. We report the first extensive purification of mtDNA ligase as a 100-kDa enzyme that functions with an enzyme-adenylate intermediate and is capable of ligating oligo(dT) strands annealed to poly(rA). These properties together with preliminary immunological evidence suggest that mtDNA may be related to nuclear DNA ligase III." @default.
• W2109323414 created "2016-06-24" @default.
• W2109323414 creator A5064165292 @default.
• W2109323414 creator A5064451780 @default.
• W2109323414 date "1998-03-01" @default.
• W2109323414 modified "2023-10-01" @default.
• W2109323414 title "Efficient Repair of Abasic Sites in DNA by Mitochondrial Enzymes" @default.
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• W2109323414 doi "https://doi.org/10.1128/mcb.18.3.1257" @default.
• W2109323414 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/108838" @default.
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