Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109332387> ?p ?o ?g. }
- W2109332387 endingPage "2795" @default.
- W2109332387 startingPage "2784" @default.
- W2109332387 abstract "The G-protein-coupled lactate receptor, GPR81 (HCA1), is known to promote lipid storage in adipocytes by downregulating cAMP levels. Here, we show that GPR81 is also present in the mammalian brain, including regions of the cerebral neocortex and hippocampus, where it can be activated by physiological concentrations of lactate and by the specific GPR81 agonist 3,5-dihydroxybenzoate to reduce cAMP. Cerebral GPR81 is concentrated on the synaptic membranes of excitatory synapses, with a postsynaptic predominance. GPR81 is also enriched at the blood-brain-barrier: the GPR81 densities at endothelial cell membranes are about twice the GPR81 density at membranes of perivascular astrocytic processes, but about one-seventh of that on synaptic membranes. There is only a slight signal in perisynaptic processes of astrocytes. In synaptic spines, as well as in adipocytes, GPR81 immunoreactivity is located on subplasmalemmal vesicular organelles, suggesting trafficking of the protein to and from the plasma membrane. The results indicate roles of lactate in brain signaling, including a neuronal glucose and glycogen saving response to the supply of lactate. We propose that lactate, through activation of GPR81 receptors, can act as a volume transmitter that links neuronal activity, cerebral energy metabolism and energy substrate availability." @default.
- W2109332387 created "2016-06-24" @default.
- W2109332387 creator A5009536111 @default.
- W2109332387 creator A5020650677 @default.
- W2109332387 creator A5026944446 @default.
- W2109332387 creator A5031079397 @default.
- W2109332387 creator A5031611004 @default.
- W2109332387 creator A5050408597 @default.
- W2109332387 creator A5051641042 @default.
- W2109332387 creator A5057005577 @default.
- W2109332387 creator A5062616210 @default.
- W2109332387 creator A5069953798 @default.
- W2109332387 date "2013-05-21" @default.
- W2109332387 modified "2023-10-14" @default.
- W2109332387 title "Lactate Receptor Sites Link Neurotransmission, Neurovascular Coupling, and Brain Energy Metabolism" @default.
- W2109332387 cites W1502364020 @default.
- W2109332387 cites W1563015028 @default.
- W2109332387 cites W1616394907 @default.
- W2109332387 cites W1965004625 @default.
- W2109332387 cites W1967932180 @default.
- W2109332387 cites W1971285535 @default.
- W2109332387 cites W1978648371 @default.
- W2109332387 cites W1990158364 @default.
- W2109332387 cites W2004993911 @default.
- W2109332387 cites W2006986579 @default.
- W2109332387 cites W2020125871 @default.
- W2109332387 cites W2021032824 @default.
- W2109332387 cites W2021595651 @default.
- W2109332387 cites W2032219138 @default.
- W2109332387 cites W2033508630 @default.
- W2109332387 cites W2037704797 @default.
- W2109332387 cites W2038392123 @default.
- W2109332387 cites W2038811384 @default.
- W2109332387 cites W2043744835 @default.
- W2109332387 cites W2048453304 @default.
- W2109332387 cites W2055172310 @default.
- W2109332387 cites W2055834061 @default.
- W2109332387 cites W2055908419 @default.
- W2109332387 cites W2056880939 @default.
- W2109332387 cites W2062420270 @default.
- W2109332387 cites W2064488696 @default.
- W2109332387 cites W2064539435 @default.
- W2109332387 cites W2064830032 @default.
- W2109332387 cites W2067898648 @default.
- W2109332387 cites W2079933309 @default.
- W2109332387 cites W2085509818 @default.
- W2109332387 cites W2086554547 @default.
- W2109332387 cites W2092635505 @default.
- W2109332387 cites W2094633691 @default.
- W2109332387 cites W2105712804 @default.
- W2109332387 cites W2109135798 @default.
- W2109332387 cites W2111636333 @default.
- W2109332387 cites W2112578326 @default.
- W2109332387 cites W2113560999 @default.
- W2109332387 cites W2114372764 @default.
- W2109332387 cites W2127626240 @default.
- W2109332387 cites W2129323165 @default.
- W2109332387 cites W2132333568 @default.
- W2109332387 cites W2136695085 @default.
- W2109332387 cites W2148611607 @default.
- W2109332387 cites W2150780140 @default.
- W2109332387 cites W2153757748 @default.
- W2109332387 cites W2161480852 @default.
- W2109332387 cites W2167207140 @default.
- W2109332387 cites W2323673341 @default.
- W2109332387 doi "https://doi.org/10.1093/cercor/bht136" @default.
- W2109332387 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23696276" @default.
- W2109332387 hasPublicationYear "2013" @default.
- W2109332387 type Work @default.
- W2109332387 sameAs 2109332387 @default.
- W2109332387 citedByCount "225" @default.
- W2109332387 countsByYear W21093323872013 @default.
- W2109332387 countsByYear W21093323872014 @default.
- W2109332387 countsByYear W21093323872015 @default.
- W2109332387 countsByYear W21093323872016 @default.
- W2109332387 countsByYear W21093323872017 @default.
- W2109332387 countsByYear W21093323872018 @default.
- W2109332387 countsByYear W21093323872019 @default.
- W2109332387 countsByYear W21093323872020 @default.
- W2109332387 countsByYear W21093323872021 @default.
- W2109332387 countsByYear W21093323872022 @default.
- W2109332387 countsByYear W21093323872023 @default.
- W2109332387 crossrefType "journal-article" @default.
- W2109332387 hasAuthorship W2109332387A5009536111 @default.
- W2109332387 hasAuthorship W2109332387A5020650677 @default.
- W2109332387 hasAuthorship W2109332387A5026944446 @default.
- W2109332387 hasAuthorship W2109332387A5031079397 @default.
- W2109332387 hasAuthorship W2109332387A5031611004 @default.
- W2109332387 hasAuthorship W2109332387A5050408597 @default.
- W2109332387 hasAuthorship W2109332387A5051641042 @default.
- W2109332387 hasAuthorship W2109332387A5057005577 @default.
- W2109332387 hasAuthorship W2109332387A5062616210 @default.
- W2109332387 hasAuthorship W2109332387A5069953798 @default.
- W2109332387 hasBestOaLocation W21093323871 @default.
- W2109332387 hasConcept C169760540 @default.
- W2109332387 hasConcept C170493617 @default.
- W2109332387 hasConcept C185592680 @default.
- W2109332387 hasConcept C200170125 @default.