Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109332925> ?p ?o ?g. }
Showing items 1 to 93 of
93
with 100 items per page.
- W2109332925 abstract "The clinical spectrum of autoimmune pituitary disease is still being defined. In the pediatric age group, autoimmune mechanisms have been postulated for some cases of growth hormone (GH) deficiency and the empty sella syndrome. The classical presentation in adulthood is of peripartum hypopituitarism associated with a pituitary mass and visual failure. Biopsy reveals lymphocytic infiltration of the pituitary, mainly with CD4+ T helper cells, and is termed lymphocytic hypophysitis. Secondary adrenal insufficiency is a prominent feature of the hypopituitarism and isolated adrenocorticotropin (ACTH) deficiency and the empty sella syndrome are thought to be endstages of the disease spectrum. There has been no specific pre-operative serological test for this condition.We have developed a new assay based on immunoblotting, for evaluating autoantibodies in pituitary disease. The assay uses autopsy pituitaries which are homogenized and ultracentrifuged to give membrance and cytosolic fractions. Proteins are immunoblotted and reactivity of patient sera to autoantigens is detected using an alkaline-phosphatase conjugated second antibody.A pituitary specific 45 kDa membrane protein was identified by serum from a child with isolated GH dificiency and an empty sella. The target autoantigen in some cases of isolated ACTH deficiency appears to be a 49 kDa cytosolic protein." @default.
- W2109332925 created "2016-06-24" @default.
- W2109332925 creator A5039602935 @default.
- W2109332925 date "1996-01-01" @default.
- W2109332925 modified "2023-09-24" @default.
- W2109332925 title "Pituitary Autoantibodies and Hypopituitarism" @default.
- W2109332925 cites W1964751322 @default.
- W2109332925 cites W1966572446 @default.
- W2109332925 cites W1978059165 @default.
- W2109332925 cites W1987211144 @default.
- W2109332925 cites W1996876600 @default.
- W2109332925 cites W1998761228 @default.
- W2109332925 cites W2004400507 @default.
- W2109332925 cites W2025260981 @default.
- W2109332925 cites W2027086169 @default.
- W2109332925 cites W2028926829 @default.
- W2109332925 cites W2030289962 @default.
- W2109332925 cites W2035349500 @default.
- W2109332925 cites W2036089795 @default.
- W2109332925 cites W2039457575 @default.
- W2109332925 cites W2040450568 @default.
- W2109332925 cites W2040906187 @default.
- W2109332925 cites W2051486863 @default.
- W2109332925 cites W2052041217 @default.
- W2109332925 cites W2056954598 @default.
- W2109332925 cites W2062346366 @default.
- W2109332925 cites W2067455005 @default.
- W2109332925 cites W2081017449 @default.
- W2109332925 cites W2102057126 @default.
- W2109332925 cites W2119353136 @default.
- W2109332925 cites W2123646724 @default.
- W2109332925 cites W2124101454 @default.
- W2109332925 cites W2152995116 @default.
- W2109332925 cites W2167892561 @default.
- W2109332925 cites W2168290363 @default.
- W2109332925 cites W2170002308 @default.
- W2109332925 cites W2395433118 @default.
- W2109332925 cites W2419171287 @default.
- W2109332925 cites W2993816361 @default.
- W2109332925 cites W2997262816 @default.
- W2109332925 doi "https://doi.org/10.1297/cpe.5.supple8_9" @default.
- W2109332925 hasPublicationYear "1996" @default.
- W2109332925 type Work @default.
- W2109332925 sameAs 2109332925 @default.
- W2109332925 citedByCount "2" @default.
- W2109332925 crossrefType "journal-article" @default.
- W2109332925 hasAuthorship W2109332925A5039602935 @default.
- W2109332925 hasBestOaLocation W21093329251 @default.
- W2109332925 hasConcept C126322002 @default.
- W2109332925 hasConcept C134018914 @default.
- W2109332925 hasConcept C142724271 @default.
- W2109332925 hasConcept C159654299 @default.
- W2109332925 hasConcept C163764329 @default.
- W2109332925 hasConcept C203014093 @default.
- W2109332925 hasConcept C2778491484 @default.
- W2109332925 hasConcept C2779431974 @default.
- W2109332925 hasConcept C71924100 @default.
- W2109332925 hasConceptScore W2109332925C126322002 @default.
- W2109332925 hasConceptScore W2109332925C134018914 @default.
- W2109332925 hasConceptScore W2109332925C142724271 @default.
- W2109332925 hasConceptScore W2109332925C159654299 @default.
- W2109332925 hasConceptScore W2109332925C163764329 @default.
- W2109332925 hasConceptScore W2109332925C203014093 @default.
- W2109332925 hasConceptScore W2109332925C2778491484 @default.
- W2109332925 hasConceptScore W2109332925C2779431974 @default.
- W2109332925 hasConceptScore W2109332925C71924100 @default.
- W2109332925 hasLocation W21093329251 @default.
- W2109332925 hasOpenAccess W2109332925 @default.
- W2109332925 hasPrimaryLocation W21093329251 @default.
- W2109332925 hasRelatedWork W1989958799 @default.
- W2109332925 hasRelatedWork W1995709589 @default.
- W2109332925 hasRelatedWork W2014839285 @default.
- W2109332925 hasRelatedWork W2023443206 @default.
- W2109332925 hasRelatedWork W2036241888 @default.
- W2109332925 hasRelatedWork W2043605554 @default.
- W2109332925 hasRelatedWork W2047109378 @default.
- W2109332925 hasRelatedWork W2051486863 @default.
- W2109332925 hasRelatedWork W2080178036 @default.
- W2109332925 hasRelatedWork W2085172491 @default.
- W2109332925 hasRelatedWork W2087676802 @default.
- W2109332925 hasRelatedWork W2090623526 @default.
- W2109332925 hasRelatedWork W2126707932 @default.
- W2109332925 hasRelatedWork W2151276811 @default.
- W2109332925 hasRelatedWork W2474491679 @default.
- W2109332925 hasRelatedWork W2558165228 @default.
- W2109332925 hasRelatedWork W2569498166 @default.
- W2109332925 hasRelatedWork W2752787214 @default.
- W2109332925 hasRelatedWork W2783411466 @default.
- W2109332925 hasRelatedWork W188618479 @default.
- W2109332925 isParatext "false" @default.
- W2109332925 isRetracted "false" @default.
- W2109332925 magId "2109332925" @default.
- W2109332925 workType "article" @default.