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• W2109333611 startingPage "1694" @default.
• W2109333611 abstract "Protein G-related α2-macroglobulin-binding (GRAB) protein is a cell wall-attached determinant of group A streptococcus (GAS) that interacts with the human protease inhibitor α2-macroglobulin (α2-M). Of 86 clinical isolates tested, 23% could bind α2-M. However, all strains tested contained the grab gene. High levels of anti-GRAB antibodies were found in the serum of convalescent GAS-infected patients, a finding that indicates that this protein is expressed during the infection process. Among the α2-M-binding strains, 80% were skin isolates, and 20% were throat isolates, findings that suggest that the skin environment is a preferential site for expression of α2-M-binding activity. To test this possibility, we determined the role of GRAB in a mouse model of GAS skin infection. The wild-type strain KTL3, which interacts with α2-M, showed high virulence. The isogenic mutant of KTL3, MR4, devoid of surface-bound GRAB, was attenuated in virulence, compared with the wild-type strain. Thus, mice infected with MR4 survived longer, developed smaller skin lesions, and exhibited lower levels of bacterial dissemination than did those infected with KTL3. These results emphasize the role of GRAB as a virulence factor of GAS" @default.
• W2109333611 created "2016-06-24" @default.
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• W2109333611 date "2003-06-01" @default.
• W2109333611 modified "2023-09-26" @default.
• W2109333611 title "Contribution of Protein G–Related α₂‐Macroglobulin–Binding Protein to Bacterial Virulence in a Mouse Skin Model of Group A Streptococcal Infection" @default.
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• W2109333611 doi "https://doi.org/10.1086/375029" @default.
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• W2109333611 hasPublicationYear "2003" @default.
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