FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109338978> ?p ?o ?g. }

• W2109338978 endingPage "835" @default.
• W2109338978 startingPage "829" @default.
• W2109338978 abstract "Inflammation-induced articular cartilage degradation is a major problem in rheumatoid arthritis (RA). Type 1 T cell activity (characterized by interferon-gamma/interleukin-2 [IL-2] production), and consequently, the production of the proinflammatory cytokines IL-1 and tumor necrosis factor alpha (TNF alpha), have been reported to play a major role in cartilage damage. IL-10 and IL-4, both produced by type 2 T cells, are cytokines with the capacity to down-regulate proinflammatory responses. The present study was undertaken to investigate the way in which these cytokines affect activated mononuclear cells (MNC) of RA patients in relation to human articular cartilage degradation in vitro.MNC from synovial fluid and peripheral blood of RA patients were stimulated with bacterial antigen and treated with IL-10 and/or IL-4. Bacterial antigen is known to activate type 1 T cells and to induce proinflammatory IL-1/TNF alpha-dependent cartilage damage. Cytokine production and effects of conditioned media, as well as effects of IL-10 and IL-4 on proteoglycan (PG) turnover (as a measure for cartilage damage), were determined.IL-10 and IL-4 inhibited proinflammatory cytokine production of stimulated RA MNC and completely reversed inhibition of cartilage PG synthesis induced by these stimulated RA MNC. IL-10 was more potent than IL-4 in this respect, and the combination of IL-10 and IL-4 had an additive effect. In addition, IL-10 directly stimulated cartilage PG synthesis.IL-10 reverses the cartilage degradation induced by antigen-stimulated MNC, and IL-4 has an additive effect on this process. Furthermore, IL-10 has a direct stimulatory effect on PG synthesis, and IL-4, as a growth factor for type 2 T cells, can reduce the ratio of type 1 to type 2 T cell activity. These results provide evidence in favor of the use of a combination of the two cytokines in the treatment of RA." @default.
• W2109338978 created "2016-06-24" @default.
• W2109338978 creator A5006690451 @default.
• W2109338978 creator A5017043157 @default.
• W2109338978 creator A5032942149 @default.
• W2109338978 creator A5063928355 @default.
• W2109338978 creator A5081349339 @default.
• W2109338978 date "1996-05-01" @default.
• W2109338978 modified "2023-09-27" @default.
• W2109338978 title "Prevention and reversal of cartilage degradation in rheumatoid arthritis by interleukin-10 and interleukin-4" @default.
• W2109338978 cites W1806272426 @default.
• W2109338978 cites W1975534320 @default.
• W2109338978 cites W1988280501 @default.
• W2109338978 cites W1990173399 @default.
• W2109338978 cites W1996794055 @default.
• W2109338978 cites W2004966953 @default.
• W2109338978 cites W2005324550 @default.
• W2109338978 cites W2006831045 @default.
• W2109338978 cites W2008354469 @default.
• W2109338978 cites W2011038290 @default.
• W2109338978 cites W2028101339 @default.
• W2109338978 cites W2053538354 @default.
• W2109338978 cites W2090104922 @default.
• W2109338978 cites W2095351296 @default.
• W2109338978 cites W2103210336 @default.
• W2109338978 cites W2104899331 @default.
• W2109338978 cites W2141914481 @default.
• W2109338978 cites W2142273705 @default.
• W2109338978 cites W2147594482 @default.
• W2109338978 cites W2152348310 @default.
• W2109338978 cites W2153639301 @default.
• W2109338978 cites W2158128491 @default.
• W2109338978 cites W2161854417 @default.
• W2109338978 cites W2163440809 @default.
• W2109338978 cites W2175077154 @default.
• W2109338978 cites W2191654227 @default.
• W2109338978 cites W4231581694 @default.
• W2109338978 cites W4248044859 @default.
• W2109338978 doi "https://doi.org/10.1002/art.1780390516" @default.
• W2109338978 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8639180" @default.
• W2109338978 hasPublicationYear "1996" @default.
• W2109338978 type Work @default.
• W2109338978 sameAs 2109338978 @default.
• W2109338978 citedByCount "166" @default.
• W2109338978 countsByYear W21093389782012 @default.
• W2109338978 countsByYear W21093389782013 @default.
• W2109338978 countsByYear W21093389782014 @default.
• W2109338978 countsByYear W21093389782015 @default.
• W2109338978 countsByYear W21093389782016 @default.
• W2109338978 countsByYear W21093389782017 @default.
• W2109338978 countsByYear W21093389782018 @default.
• W2109338978 countsByYear W21093389782019 @default.
• W2109338978 countsByYear W21093389782020 @default.
• W2109338978 countsByYear W21093389782021 @default.
• W2109338978 countsByYear W21093389782022 @default.
• W2109338978 countsByYear W21093389782023 @default.
• W2109338978 crossrefType "journal-article" @default.
• W2109338978 hasAuthorship W2109338978A5006690451 @default.
• W2109338978 hasAuthorship W2109338978A5017043157 @default.
• W2109338978 hasAuthorship W2109338978A5032942149 @default.
• W2109338978 hasAuthorship W2109338978A5063928355 @default.
• W2109338978 hasAuthorship W2109338978A5081349339 @default.
• W2109338978 hasBestOaLocation W21093389781 @default.
• W2109338978 hasConcept C105702510 @default.
• W2109338978 hasConcept C142724271 @default.
• W2109338978 hasConcept C164027704 @default.
• W2109338978 hasConcept C17991360 @default.
• W2109338978 hasConcept C185592680 @default.
• W2109338978 hasConcept C203014093 @default.
• W2109338978 hasConcept C204787440 @default.
• W2109338978 hasConcept C2776164576 @default.
• W2109338978 hasConcept C2776268809 @default.
• W2109338978 hasConcept C2776914184 @default.
• W2109338978 hasConcept C2777077863 @default.
• W2109338978 hasConcept C2777575956 @default.
• W2109338978 hasConcept C2778690821 @default.
• W2109338978 hasConcept C2780550940 @default.
• W2109338978 hasConcept C71924100 @default.
• W2109338978 hasConcept C74172505 @default.
• W2109338978 hasConceptScore W2109338978C105702510 @default.
• W2109338978 hasConceptScore W2109338978C142724271 @default.
• W2109338978 hasConceptScore W2109338978C164027704 @default.
• W2109338978 hasConceptScore W2109338978C17991360 @default.
• W2109338978 hasConceptScore W2109338978C185592680 @default.
• W2109338978 hasConceptScore W2109338978C203014093 @default.
• W2109338978 hasConceptScore W2109338978C204787440 @default.
• W2109338978 hasConceptScore W2109338978C2776164576 @default.
• W2109338978 hasConceptScore W2109338978C2776268809 @default.
• W2109338978 hasConceptScore W2109338978C2776914184 @default.
• W2109338978 hasConceptScore W2109338978C2777077863 @default.
• W2109338978 hasConceptScore W2109338978C2777575956 @default.
• W2109338978 hasConceptScore W2109338978C2778690821 @default.
• W2109338978 hasConceptScore W2109338978C2780550940 @default.
• W2109338978 hasConceptScore W2109338978C71924100 @default.
• W2109338978 hasConceptScore W2109338978C74172505 @default.
• W2109338978 hasIssue "5" @default.
• W2109338978 hasLocation W21093389781 @default.
• W2109338978 hasLocation W21093389782 @default.

• next