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• W2109343217 startingPage "920" @default.
• W2109343217 abstract "Most Swan-Ganz pulmonary artery catheters have heparin bonded to the surface with benzalkonium chloride, a cationic surfactant, to reduce thrombosis. Since benzalkonium is bactericidal, the antimicrobial activity of heparin-bonded pulmonary artery catheters was investigated in an in vitro assay. Each catheter exhibited activity against a wide variety of potential microbial pathogens, including Candida albicans. The magnitude of activity against individual organisms correlated strongly with their in vitro susceptibility to benzalkonium chloride (r = .94, P < .002). A chlorhexidine-silver sulfadiazine-impregnated catheter exhibited even greater activity than the heparin-bonded catheters (P = .01). When exposed to serum for 24 h, heparin-bonded catheters lost ⩾50% of their antimicrobial activity, whereas the activity of the chlorhexidine-silver sulfadiazine- impregnated catheter was minimally affected. The fortuitous surface antimicrobial activity of heparin-bonded catheters may account for the low incidence of catheter-related bacteremia (mean, 1.0%) compared with Swan-Ganz catheters of the same materials but not coated with benzalkonium-heparin (mean, 2.8%)." @default.
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• W2109343217 date "1993-04-01" @default.
• W2109343217 modified "2023-10-16" @default.
• W2109343217 title "Surface Antimicrobial Activity of Heparin-Bonded and Antiseptic-Impregnated Vascular Catheters" @default.
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• W2109343217 doi "https://doi.org/10.1093/infdis/167.4.920" @default.
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