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- W2109347706 abstract "ABSTRACT DNA vaccination elicits humoral and cellular immune responses and has been shown to confer protection against several viral, bacterial, and parasitic pathogens. Here we report that optimized codon usage of an injected DNA sequence considerably increases both humoral and cellular immune responses. We recently generated a synthetic human immunodeficiency virus type 1 gp120 sequence in which most wild-type codons were replaced with codons from highly expressed human genes (syngp120). In vitro expression of syngp120 is considerably increased in comparison to that of the respective wild-type sequence. In BALB/c mice, DNA immunization with syngp120 resulted in significantly increased antibody titers and cytotoxic T-lymphocyte reactivity, suggesting a direct correlation between expression levels and the immune response. Moreover, syngp120 is characterized by rev -independent expression and a low risk of recombination with viral sequences. Thus, synthetic genes with optimized codon usage represent a novel strategy to increase the efficacy and safety of DNA vaccination." @default.
- W2109347706 created "2016-06-24" @default.
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- W2109347706 creator A5036618159 @default.
- W2109347706 creator A5075642890 @default.
- W2109347706 creator A5090399098 @default.
- W2109347706 date "1998-02-01" @default.
- W2109347706 modified "2023-10-18" @default.
- W2109347706 title "Increased Immune Response Elicited by DNA Vaccination with a Synthetic gp120 Sequence with Optimized Codon Usage" @default.
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- W2109347706 doi "https://doi.org/10.1128/jvi.72.2.1497-1503.1998" @default.
- W2109347706 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/124631" @default.
- W2109347706 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9445053" @default.
- W2109347706 hasPublicationYear "1998" @default.
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