Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109350845> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2109350845 endingPage "1438" @default.
- W2109350845 startingPage "1429" @default.
- W2109350845 abstract "Immunological tolerance was induced in adult mice by the injection of 5 mg of deaggregated hapten-protein conjugate. The tolerant state was confirmed 4-19 days later by the failure of such animals to mount an immune response against an aggregated form of the same thymus-dependent hapten-protein conjugate as well as by the inability of spleen cells from tolerant animals to respond to a thymus-independent hapten-carrier conjugate. Even though the animals were fully tolerant, their spleen cells were activated by lipopolysaccharide (LPS) in vitro to produce normal numbers of plaque-forming cells against the hapten. The finding that spleen cells from tolerant animals could be activated by LPS into synthesis of antibodies against the tolerogen indicates that tolerance to thymus-dependent antigens does not affect B cells, but presumably only T cells. It is suggested that the only stringent test for the existence of B-cell tolerance is the inability of polyclonal B-cell activators to activate antibody synthesis against the tolerogen. The findings make it unlikely that B-cell tolerance to autologous thymus-dependent antigens exists and further indicate that such antigens cannot deliver activating or tolerogenic signals to B cells, although they are competent to combine with and block the Ig receptors." @default.
- W2109350845 created "2016-06-24" @default.
- W2109350845 creator A5008915149 @default.
- W2109350845 creator A5019865629 @default.
- W2109350845 creator A5026579903 @default.
- W2109350845 creator A5031572164 @default.
- W2109350845 creator A5046938695 @default.
- W2109350845 creator A5090210027 @default.
- W2109350845 creator A5091040882 @default.
- W2109350845 date "1976-06-01" @default.
- W2109350845 modified "2023-10-14" @default.
- W2109350845 title "Spleen cells from animals tolerant to a thymus-dependent antigen can be activated by lipopolysaccharide to synthesize antibodies against the tolerogen." @default.
- W2109350845 cites W1536996448 @default.
- W2109350845 cites W1582723580 @default.
- W2109350845 cites W1590734290 @default.
- W2109350845 cites W1979981530 @default.
- W2109350845 cites W1982646981 @default.
- W2109350845 cites W1985205295 @default.
- W2109350845 cites W2002403281 @default.
- W2109350845 cites W2015152188 @default.
- W2109350845 cites W2030746373 @default.
- W2109350845 cites W2033478337 @default.
- W2109350845 cites W2035862844 @default.
- W2109350845 cites W2036363305 @default.
- W2109350845 cites W2037232132 @default.
- W2109350845 cites W2050573067 @default.
- W2109350845 cites W2055408664 @default.
- W2109350845 cites W2060466064 @default.
- W2109350845 cites W2065876542 @default.
- W2109350845 cites W2112887904 @default.
- W2109350845 cites W2141155302 @default.
- W2109350845 cites W2143854597 @default.
- W2109350845 doi "https://doi.org/10.1084/jem.143.6.1429" @default.
- W2109350845 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2190202" @default.
- W2109350845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/775013" @default.
- W2109350845 hasPublicationYear "1976" @default.
- W2109350845 type Work @default.
- W2109350845 sameAs 2109350845 @default.
- W2109350845 citedByCount "70" @default.
- W2109350845 countsByYear W21093508452012 @default.
- W2109350845 crossrefType "journal-article" @default.
- W2109350845 hasAuthorship W2109350845A5008915149 @default.
- W2109350845 hasAuthorship W2109350845A5019865629 @default.
- W2109350845 hasAuthorship W2109350845A5026579903 @default.
- W2109350845 hasAuthorship W2109350845A5031572164 @default.
- W2109350845 hasAuthorship W2109350845A5046938695 @default.
- W2109350845 hasAuthorship W2109350845A5090210027 @default.
- W2109350845 hasAuthorship W2109350845A5091040882 @default.
- W2109350845 hasBestOaLocation W21093508451 @default.
- W2109350845 hasConcept C147483822 @default.
- W2109350845 hasConcept C153911025 @default.
- W2109350845 hasConcept C159654299 @default.
- W2109350845 hasConcept C203014093 @default.
- W2109350845 hasConcept C2777702733 @default.
- W2109350845 hasConcept C2778453870 @default.
- W2109350845 hasConcept C2778754761 @default.
- W2109350845 hasConcept C2780931953 @default.
- W2109350845 hasConcept C29144244 @default.
- W2109350845 hasConcept C86803240 @default.
- W2109350845 hasConcept C8891405 @default.
- W2109350845 hasConceptScore W2109350845C147483822 @default.
- W2109350845 hasConceptScore W2109350845C153911025 @default.
- W2109350845 hasConceptScore W2109350845C159654299 @default.
- W2109350845 hasConceptScore W2109350845C203014093 @default.
- W2109350845 hasConceptScore W2109350845C2777702733 @default.
- W2109350845 hasConceptScore W2109350845C2778453870 @default.
- W2109350845 hasConceptScore W2109350845C2778754761 @default.
- W2109350845 hasConceptScore W2109350845C2780931953 @default.
- W2109350845 hasConceptScore W2109350845C29144244 @default.
- W2109350845 hasConceptScore W2109350845C86803240 @default.
- W2109350845 hasConceptScore W2109350845C8891405 @default.
- W2109350845 hasIssue "6" @default.
- W2109350845 hasLocation W21093508451 @default.
- W2109350845 hasLocation W21093508452 @default.
- W2109350845 hasLocation W21093508453 @default.
- W2109350845 hasLocation W21093508454 @default.
- W2109350845 hasOpenAccess W2109350845 @default.
- W2109350845 hasPrimaryLocation W21093508451 @default.
- W2109350845 hasRelatedWork W1517487682 @default.
- W2109350845 hasRelatedWork W1976832055 @default.
- W2109350845 hasRelatedWork W1981415889 @default.
- W2109350845 hasRelatedWork W1990058423 @default.
- W2109350845 hasRelatedWork W2044309065 @default.
- W2109350845 hasRelatedWork W2063245208 @default.
- W2109350845 hasRelatedWork W2144264324 @default.
- W2109350845 hasRelatedWork W2395449481 @default.
- W2109350845 hasRelatedWork W4313309038 @default.
- W2109350845 hasRelatedWork W4313348107 @default.
- W2109350845 hasVolume "143" @default.
- W2109350845 isParatext "false" @default.
- W2109350845 isRetracted "false" @default.
- W2109350845 magId "2109350845" @default.
- W2109350845 workType "article" @default.