Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109352698> ?p ?o ?g. }
- W2109352698 endingPage "149" @default.
- W2109352698 startingPage "139" @default.
- W2109352698 abstract "Based on in vitro synergy studies, the addition of nafcillin to daptomycin was used to treat refractory methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Daptomycin is a de facto cationic antimicrobial peptide in vivo, with antistaphylococcal mechanisms reminiscent of innate host defense peptides (HDPs). In this study, the effects of nafcillin on HDP activity against MRSA were examined in vitro and in vivo. Exposures to β-lactam antimicrobials in general, and nafcillin in particular, significantly increased killing of S. aureus by selected HDPs from keratinocytes, neutrophils, and platelets. This finding correlated with enhanced killing of MRSA by whole blood, neutrophils, and keratinocytes after growth in nafcillin. Finally, nafcillin pretreatment ex vivo reduced MRSA virulence in a murine subcutaneous infection model. Despite the lack of direct activity against MRSA, these studies show potent, consistent, and generalized nafcillin-mediated “sensitization” to increased killing of MRSA by various components of the innate host response. The use of nafcillin as adjunctive therapy in MRSA bacteremia merits further study and should be considered in cases refractory to standard therapy." @default.
- W2109352698 created "2016-06-24" @default.
- W2109352698 creator A5004599263 @default.
- W2109352698 creator A5006079772 @default.
- W2109352698 creator A5012131316 @default.
- W2109352698 creator A5017445754 @default.
- W2109352698 creator A5018305386 @default.
- W2109352698 creator A5021031438 @default.
- W2109352698 creator A5049520675 @default.
- W2109352698 creator A5067852918 @default.
- W2109352698 creator A5069414574 @default.
- W2109352698 creator A5076276224 @default.
- W2109352698 creator A5084343092 @default.
- W2109352698 creator A5089711302 @default.
- W2109352698 date "2013-12-03" @default.
- W2109352698 modified "2023-10-01" @default.
- W2109352698 title "Nafcillin enhances innate immune-mediated killing of methicillin-resistant Staphylococcus aureus" @default.
- W2109352698 cites W154298887 @default.
- W2109352698 cites W1844316610 @default.
- W2109352698 cites W1917119829 @default.
- W2109352698 cites W1964758221 @default.
- W2109352698 cites W1970747983 @default.
- W2109352698 cites W1972348080 @default.
- W2109352698 cites W1977550761 @default.
- W2109352698 cites W1984936173 @default.
- W2109352698 cites W1990880480 @default.
- W2109352698 cites W2001291684 @default.
- W2109352698 cites W2007331931 @default.
- W2109352698 cites W2011424867 @default.
- W2109352698 cites W2040559263 @default.
- W2109352698 cites W2044368480 @default.
- W2109352698 cites W2044467699 @default.
- W2109352698 cites W2045190713 @default.
- W2109352698 cites W2051284724 @default.
- W2109352698 cites W2053772103 @default.
- W2109352698 cites W2060715734 @default.
- W2109352698 cites W2063172021 @default.
- W2109352698 cites W2077590888 @default.
- W2109352698 cites W2081380761 @default.
- W2109352698 cites W2082441919 @default.
- W2109352698 cites W2091858071 @default.
- W2109352698 cites W2094036101 @default.
- W2109352698 cites W2098607423 @default.
- W2109352698 cites W2103844198 @default.
- W2109352698 cites W2108433768 @default.
- W2109352698 cites W2113063737 @default.
- W2109352698 cites W2113651812 @default.
- W2109352698 cites W2114585210 @default.
- W2109352698 cites W2116412084 @default.
- W2109352698 cites W2116607488 @default.
- W2109352698 cites W2117913801 @default.
- W2109352698 cites W2119407878 @default.
- W2109352698 cites W2123219109 @default.
- W2109352698 cites W2124620023 @default.
- W2109352698 cites W2125066910 @default.
- W2109352698 cites W2130037065 @default.
- W2109352698 cites W2133902131 @default.
- W2109352698 cites W2138666908 @default.
- W2109352698 cites W2139615718 @default.
- W2109352698 cites W2143464946 @default.
- W2109352698 cites W2145726848 @default.
- W2109352698 cites W2146598854 @default.
- W2109352698 cites W2150865677 @default.
- W2109352698 cites W2151150074 @default.
- W2109352698 cites W2153333781 @default.
- W2109352698 cites W2155864378 @default.
- W2109352698 cites W2162000793 @default.
- W2109352698 cites W2168482920 @default.
- W2109352698 cites W2168625432 @default.
- W2109352698 cites W2317442762 @default.
- W2109352698 cites W326456734 @default.
- W2109352698 cites W4232734499 @default.
- W2109352698 doi "https://doi.org/10.1007/s00109-013-1100-7" @default.
- W2109352698 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3926703" @default.
- W2109352698 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24297496" @default.
- W2109352698 hasPublicationYear "2013" @default.
- W2109352698 type Work @default.
- W2109352698 sameAs 2109352698 @default.
- W2109352698 citedByCount "113" @default.
- W2109352698 countsByYear W21093526982014 @default.
- W2109352698 countsByYear W21093526982015 @default.
- W2109352698 countsByYear W21093526982016 @default.
- W2109352698 countsByYear W21093526982017 @default.
- W2109352698 countsByYear W21093526982018 @default.
- W2109352698 countsByYear W21093526982019 @default.
- W2109352698 countsByYear W21093526982020 @default.
- W2109352698 countsByYear W21093526982021 @default.
- W2109352698 countsByYear W21093526982022 @default.
- W2109352698 countsByYear W21093526982023 @default.
- W2109352698 crossrefType "journal-article" @default.
- W2109352698 hasAuthorship W2109352698A5004599263 @default.
- W2109352698 hasAuthorship W2109352698A5006079772 @default.
- W2109352698 hasAuthorship W2109352698A5012131316 @default.
- W2109352698 hasAuthorship W2109352698A5017445754 @default.
- W2109352698 hasAuthorship W2109352698A5018305386 @default.
- W2109352698 hasAuthorship W2109352698A5021031438 @default.
- W2109352698 hasAuthorship W2109352698A5049520675 @default.
- W2109352698 hasAuthorship W2109352698A5067852918 @default.