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• W2109352883 abstract "Reductions in the capacity of the human choline transporter (SLC5A7, CHT) have been hypothesized to diminish cortical cholinergic neurotransmission, leading to risk for cognitive and mood disorders. To determine the acetylcholine (ACh) release capacity of cortical cholinergic projections in a mouse model of cholinergic hypofunction, the CHT+/- mouse, we assessed extracellular ACh levels while mice performed an operant sustained attention task (SAT). We found that whereas SAT-performance-associated increases in extracellular ACh levels of CHT+/- mice were significantly attenuated relative to wildtype littermates, performance on the SAT was normal. Tetrodotoxin-induced blockade of neuronal excitability reduced both dialysate ACh levels and SAT performance similarly in both genotypes. Likewise, lesions of cholinergic neurons abolished SAT performance in both genotypes. However, cholinergic activation remained more vulnerable to the reverse-dialyzed muscarinic antagonist atropine in CHT+/- mice. Additionally, CHT+/- mice displayed greater SAT-disrupting effects of reverse dialysis of the nAChR antagonist mecamylamine. Receptor binding assays revealed a higher density of α4β2* nAChRs in the cortex of CHT+/- mice compared to controls. These findings reveal compensatory mechanisms that, in the context of moderate cognitive challenges, can overcome the performance deficits expected from the significantly reduced ACh capacity of CHT+/- cholinergic terminals. Further analyses of molecular and functional compensations in the CHT+/- model may provide insights into both risk and resiliency factors involved in cognitive and mood disorders." @default.
• W2109352883 created "2016-06-24" @default.
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• W2109352883 creator A5074463122 @default.
• W2109352883 creator A5079071241 @default.
• W2109352883 date "2013-12-01" @default.
• W2109352883 modified "2023-09-27" @default.
• W2109352883 title "Monitoring cholinergic activity during attentional performance in mice heterozygous for the choline transporter: A model of cholinergic capacity limits" @default.
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• W2109352883 doi "https://doi.org/10.1016/j.neuropharm.2013.07.032" @default.
• W2109352883 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3865115" @default.
• W2109352883 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23958450" @default.
• W2109352883 hasPublicationYear "2013" @default.
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