Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109356985> ?p ?o ?g. }
- W2109356985 endingPage "1509" @default.
- W2109356985 startingPage "1499" @default.
- W2109356985 abstract "The brain is a common target of metastases for melanoma patients. Little is known about the genetic and epigenetic alterations in melanoma brain metastases (MBMs). Unraveling these molecular alterations is a key step in understanding their aggressive nature and identifying novel therapeutic targets. Genome-wide DNA methylation analyses of MBMs (n = 15) and normal brain tissues (n = 91) and simultaneous multigene DNA methylation and gene deletion analyses of metastatic melanoma tissues (99 MBMs and 43 extracranial metastases) were performed. BRAF and NRAS mutations were evaluated in MBMs by targeted sequencing. MBMs showed significant epigenetic heterogeneity. RARB, RASSF1, ESR1, APC, PTEN, and CDH13 genes were frequently hypermethylated. Deletions were frequently detected in the CDKN2A/B locus. Of MBMs, 46.1% and 28.8% had BRAF and NRAS missense mutations, respectively. Compared with lung and liver metastases, MBMs exhibited higher frequency of CDH13 hypermethylation and CDKN2A/B locus deletion. Mutual exclusivity between hypermethylated genes and CDKN2A/B locus deletion identified 2 clinically relevant molecular subtypes of MBMs. CDKN2A/B deletions were associated with multiple MBMs and frequently hypermethylated genes with shorter time to brain metastasis. Melanoma cells that colonize the brain harbor numerous genetically and epigenetically altered genes. This study presents an integrated genomic and epigenomic analysis that reveals MBM-specific molecular alterations and mutually exclusive molecular subtypes." @default.
- W2109356985 created "2016-06-24" @default.
- W2109356985 creator A5001606920 @default.
- W2109356985 creator A5029428307 @default.
- W2109356985 creator A5029587791 @default.
- W2109356985 creator A5034641530 @default.
- W2109356985 creator A5035263718 @default.
- W2109356985 creator A5035375520 @default.
- W2109356985 creator A5055849515 @default.
- W2109356985 creator A5056811258 @default.
- W2109356985 creator A5059782001 @default.
- W2109356985 creator A5066155034 @default.
- W2109356985 creator A5067292024 @default.
- W2109356985 creator A5083653505 @default.
- W2109356985 creator A5085227514 @default.
- W2109356985 date "2014-06-26" @default.
- W2109356985 modified "2023-10-17" @default.
- W2109356985 title "DNA methylation and gene deletion analysis of brain metastases in melanoma patients identifies mutually exclusive molecular alterations" @default.
- W2109356985 cites W1516095885 @default.
- W2109356985 cites W1642085743 @default.
- W2109356985 cites W1974079495 @default.
- W2109356985 cites W1974798136 @default.
- W2109356985 cites W1984710781 @default.
- W2109356985 cites W1989296635 @default.
- W2109356985 cites W2015457060 @default.
- W2109356985 cites W2017246865 @default.
- W2109356985 cites W2018419725 @default.
- W2109356985 cites W2030330538 @default.
- W2109356985 cites W2038286991 @default.
- W2109356985 cites W2051149841 @default.
- W2109356985 cites W2051483319 @default.
- W2109356985 cites W2057583809 @default.
- W2109356985 cites W2057818550 @default.
- W2109356985 cites W2059476232 @default.
- W2109356985 cites W2059808683 @default.
- W2109356985 cites W2064756496 @default.
- W2109356985 cites W2067893090 @default.
- W2109356985 cites W2091100650 @default.
- W2109356985 cites W2103220202 @default.
- W2109356985 cites W2108281054 @default.
- W2109356985 cites W2109816625 @default.
- W2109356985 cites W2117692326 @default.
- W2109356985 cites W2119204417 @default.
- W2109356985 cites W2119883345 @default.
- W2109356985 cites W2124359985 @default.
- W2109356985 cites W2132582013 @default.
- W2109356985 cites W2140219654 @default.
- W2109356985 cites W2141758639 @default.
- W2109356985 cites W2145657367 @default.
- W2109356985 cites W2149071620 @default.
- W2109356985 cites W2149793889 @default.
- W2109356985 cites W2152642144 @default.
- W2109356985 cites W2160379492 @default.
- W2109356985 cites W2163125612 @default.
- W2109356985 cites W2164011719 @default.
- W2109356985 cites W2165107269 @default.
- W2109356985 cites W2171902538 @default.
- W2109356985 cites W2171981493 @default.
- W2109356985 doi "https://doi.org/10.1093/neuonc/nou107" @default.
- W2109356985 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4201072" @default.
- W2109356985 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24968695" @default.
- W2109356985 hasPublicationYear "2014" @default.
- W2109356985 type Work @default.
- W2109356985 sameAs 2109356985 @default.
- W2109356985 citedByCount "53" @default.
- W2109356985 countsByYear W21093569852014 @default.
- W2109356985 countsByYear W21093569852015 @default.
- W2109356985 countsByYear W21093569852017 @default.
- W2109356985 countsByYear W21093569852018 @default.
- W2109356985 countsByYear W21093569852019 @default.
- W2109356985 countsByYear W21093569852020 @default.
- W2109356985 countsByYear W21093569852021 @default.
- W2109356985 countsByYear W21093569852022 @default.
- W2109356985 countsByYear W21093569852023 @default.
- W2109356985 crossrefType "journal-article" @default.
- W2109356985 hasAuthorship W2109356985A5001606920 @default.
- W2109356985 hasAuthorship W2109356985A5029428307 @default.
- W2109356985 hasAuthorship W2109356985A5029587791 @default.
- W2109356985 hasAuthorship W2109356985A5034641530 @default.
- W2109356985 hasAuthorship W2109356985A5035263718 @default.
- W2109356985 hasAuthorship W2109356985A5035375520 @default.
- W2109356985 hasAuthorship W2109356985A5055849515 @default.
- W2109356985 hasAuthorship W2109356985A5056811258 @default.
- W2109356985 hasAuthorship W2109356985A5059782001 @default.
- W2109356985 hasAuthorship W2109356985A5066155034 @default.
- W2109356985 hasAuthorship W2109356985A5067292024 @default.
- W2109356985 hasAuthorship W2109356985A5083653505 @default.
- W2109356985 hasAuthorship W2109356985A5085227514 @default.
- W2109356985 hasBestOaLocation W21093569851 @default.
- W2109356985 hasConcept C104317684 @default.
- W2109356985 hasConcept C150194340 @default.
- W2109356985 hasConcept C190283241 @default.
- W2109356985 hasConcept C190727270 @default.
- W2109356985 hasConcept C21790070 @default.
- W2109356985 hasConcept C2777609662 @default.
- W2109356985 hasConcept C2777658100 @default.
- W2109356985 hasConcept C2780265364 @default.
- W2109356985 hasConcept C2781187634 @default.