FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109360414> ?p ?o ?g. }

• W2109360414 endingPage "23" @default.
• W2109360414 startingPage "15" @default.
• W2109360414 abstract "Males with an extra-X chromosome (Klinefelter's syndrome) frequently, although not always, have an increased prevalence of psychiatric disturbances that range from attention deficit disorder in childhood to schizophrenia or severe affective disorders during adulthood. In addition, they frequently have characteristic verbal deficits. Thus, examining brain magnetic resonance imaging (MRI) scans of these individuals may yield clues to the influence of X chromosome genes on brain structural variation corresponding to psychiatric and cognitive disorders. Eleven adult XXY and 11 age matched XY male controls were examined with a structured psychiatric interview, battery of cognitive tests, and an MRI scan. Ten of eleven of the XXY men had some form of psychiatric disturbance, four of whom had auditory hallucinations compared with none of the XY controls. Significantly smaller frontal lobe, temporal lobe, and superior temporal gyrus (STG) cortical volumes were observed bilaterally in the XXY men. In addition, diffusion tensor imaging (DTI) of white matter integrity resulted in four regions of reduced fractional anisotropy (FA) in XXY men compared with controls, three in the left hemisphere, and one on the right. These correspond to the left posterior limb of the internal capsule, bilateral anterior cingulate, and left arcuate bundle. Specific cognitive deficits in executive functioning attributable to frontal lobe integrity and verbal comprehension were noted. Thus, excess expression of one or more X chromosome genes influences both gray and white matter development in frontal and temporal lobes, as well as white matter tracts leading to them, and may in this way contribute to the executive and language deficits observed in these adults. Future prospective studies are needed to determine which gene or genes are involved and whether their expression could be modified with appropriate treatments early in life. Brain expressed genes that are known to escape inactivation on extra-X chromosomes would be prime candidates." @default.
• W2109360414 created "2016-06-24" @default.
• W2109360414 creator A5003656676 @default.
• W2109360414 creator A5010420114 @default.
• W2109360414 creator A5011863306 @default.
• W2109360414 creator A5020284532 @default.
• W2109360414 creator A5020938259 @default.
• W2109360414 creator A5033480748 @default.
• W2109360414 creator A5087096252 @default.
• W2109360414 creator A5089086108 @default.
• W2109360414 date "2005-02-23" @default.
• W2109360414 modified "2023-10-17" @default.
• W2109360414 title "Klinefelter's syndrome (XXY) as a genetic model for psychotic disorders" @default.
• W2109360414 cites W1509322390 @default.
• W2109360414 cites W1606131697 @default.
• W2109360414 cites W1966111889 @default.
• W2109360414 cites W1978365796 @default.
• W2109360414 cites W1979462403 @default.
• W2109360414 cites W1983112713 @default.
• W2109360414 cites W1985398262 @default.
• W2109360414 cites W1995944698 @default.
• W2109360414 cites W1996089794 @default.
• W2109360414 cites W1996309079 @default.
• W2109360414 cites W2001124232 @default.
• W2109360414 cites W2001865005 @default.
• W2109360414 cites W2004495469 @default.
• W2109360414 cites W2005426011 @default.
• W2109360414 cites W2015146437 @default.
• W2109360414 cites W2016185879 @default.
• W2109360414 cites W2018509312 @default.
• W2109360414 cites W2022530159 @default.
• W2109360414 cites W2026556151 @default.
• W2109360414 cites W2032011764 @default.
• W2109360414 cites W2032533758 @default.
• W2109360414 cites W2034100059 @default.
• W2109360414 cites W2040212643 @default.
• W2109360414 cites W2051907854 @default.
• W2109360414 cites W2053341078 @default.
• W2109360414 cites W2060769810 @default.
• W2109360414 cites W2074966252 @default.
• W2109360414 cites W2078813674 @default.
• W2109360414 cites W2082078122 @default.
• W2109360414 cites W2085939973 @default.
• W2109360414 cites W2097066680 @default.
• W2109360414 cites W2101896520 @default.
• W2109360414 cites W2109704390 @default.
• W2109360414 cites W2111985746 @default.
• W2109360414 cites W2117140276 @default.
• W2109360414 cites W2123768186 @default.
• W2109360414 cites W2126255160 @default.
• W2109360414 cites W2139921097 @default.
• W2109360414 cites W2141872203 @default.
• W2109360414 cites W2142168037 @default.
• W2109360414 cites W2154497083 @default.
• W2109360414 cites W2155032878 @default.
• W2109360414 cites W2164757388 @default.
• W2109360414 cites W2166503586 @default.
• W2109360414 cites W2171257150 @default.
• W2109360414 cites W2171446692 @default.
• W2109360414 cites W2397175731 @default.
• W2109360414 cites W2399624761 @default.
• W2109360414 cites W2916416762 @default.
• W2109360414 cites W4234966166 @default.
• W2109360414 doi "https://doi.org/10.1002/ajmg.b.30163" @default.
• W2109360414 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15729733" @default.
• W2109360414 hasPublicationYear "2005" @default.
• W2109360414 type Work @default.
• W2109360414 sameAs 2109360414 @default.
• W2109360414 citedByCount "131" @default.
• W2109360414 countsByYear W21093604142012 @default.
• W2109360414 countsByYear W21093604142013 @default.
• W2109360414 countsByYear W21093604142014 @default.
• W2109360414 countsByYear W21093604142015 @default.
• W2109360414 countsByYear W21093604142016 @default.
• W2109360414 countsByYear W21093604142017 @default.
• W2109360414 countsByYear W21093604142018 @default.
• W2109360414 countsByYear W21093604142019 @default.
• W2109360414 countsByYear W21093604142020 @default.
• W2109360414 countsByYear W21093604142021 @default.
• W2109360414 countsByYear W21093604142022 @default.
• W2109360414 countsByYear W21093604142023 @default.
• W2109360414 crossrefType "journal-article" @default.
• W2109360414 hasAuthorship W2109360414A5003656676 @default.
• W2109360414 hasAuthorship W2109360414A5010420114 @default.
• W2109360414 hasAuthorship W2109360414A5011863306 @default.
• W2109360414 hasAuthorship W2109360414A5020284532 @default.
• W2109360414 hasAuthorship W2109360414A5020938259 @default.
• W2109360414 hasAuthorship W2109360414A5033480748 @default.
• W2109360414 hasAuthorship W2109360414A5087096252 @default.
• W2109360414 hasAuthorship W2109360414A5089086108 @default.
• W2109360414 hasConcept C118552586 @default.
• W2109360414 hasConcept C126838900 @default.
• W2109360414 hasConcept C14216870 @default.
• W2109360414 hasConcept C143409427 @default.
• W2109360414 hasConcept C15744967 @default.
• W2109360414 hasConcept C169900460 @default.
• W2109360414 hasConcept C2777127467 @default.
• W2109360414 hasConcept C2778186239 @default.

• next