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• W2109385147 startingPage "1183" @default.
• W2109385147 abstract "HI-6 is an oxime experimentally developed for reactivation of previously untreatable soman-phosphorylated acetylcholinesterase. It has been shown to be effective in restoring acetylcholinesterase activity after poisoning with other nerve agents namely VX and sarin; however, its antidotal qualities for the treatment of organophosphorus pesticide poisoning are not well known. HI-6, and other H-series oximes, apparently act in a number of ways: reactivation of acetylcholinesterase, blockage of ganglia and muscarinic receptors, stimulation of vasopressor and respiratory centre receptors, chemical combination with agents, restoration of neuromuscular transmission, retardation of the formation of the aged inhibitor-enzyme complex, and (or) inhibition of the release of acetylcholine." @default.
• W2109385147 created "2016-06-24" @default.
• W2109385147 creator A5001428210 @default.
• W2109385147 creator A5024974951 @default.
• W2109385147 date "1989-10-01" @default.
• W2109385147 modified "2023-09-26" @default.
• W2109385147 title "Pharmacology of HI-6, an H-series oxime" @default.
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• W2109385147 doi "https://doi.org/10.1139/y89-188" @default.
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