FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109388713> ?p ?o ?g. }

• W2109388713 endingPage "361" @default.
• W2109388713 startingPage "353" @default.
• W2109388713 abstract "AIB1 (SRC-3) is an estrogen receptor (ER) coactivator that, when overexpressed in cultured cells, can reduce the antagonist activity of tamoxifen-bound ERs. Signaling through the HER-2 receptor pathway activates AIB1 by phosphorylation. To determine whether high AIB1 expression alone or together with HER-2 reduces the effectiveness of tamoxifen in breast cancer patients, we quantified expression of AIB1 and HER-2 in tumors from breast cancer patients with long-term clinical follow-up who received either no adjuvant therapy or adjuvant tamoxifen therapy after breast cancer surgery.AIB1 and HER-2 protein levels in tumors from 316 breast cancer patients were determined using western blot analysis. Molecular variables (e.g., expression of AIB1, ER, progesterone receptor, p53, Bcl-2), tumor characteristics, and patient outcome were assessed using Spearman rank correlation. Disease-free survival (DFS) curves were derived from Kaplan-Meier estimates, and the curves were compared by log-rank tests. The effect of AIB1 on DFS adjusted for other prognostic factors was assessed by multivariable analysis using the Cox proportional hazards model. All statistical tests were two-sided.High AIB1 expression in patients not receiving adjuvant tamoxifen therapy was associated with better prognosis and longer DFS (P =.018, log-rank test). In contrast, for patients who did receive tamoxifen therapy, high AIB1 expression was associated with worse DFS (P =.049, log-rank test), which is indicative of tamoxifen resistance. The test for interaction between AIB1 expression and tamoxifen therapy was statistically significant (P =.004). When expression of AIB1 and HER-2 were considered together, patients whose tumors expressed high levels of both AIB1 and HER-2 had worse outcomes with tamoxifen therapy than all other patients combined (P =.002, log-rank test).The antitumor activity of tamoxifen in patients with breast cancer may be determined, in part, by tumor levels of AIB1 and HER-2. Thus, AIB1 may be an important diagnostic and therapeutic target." @default.
• W2109388713 created "2016-06-24" @default.
• W2109388713 creator A5004386291 @default.
• W2109388713 creator A5006635460 @default.
• W2109388713 creator A5017963342 @default.
• W2109388713 creator A5026576818 @default.
• W2109388713 creator A5027914471 @default.
• W2109388713 creator A5030115311 @default.
• W2109388713 creator A5047798037 @default.
• W2109388713 creator A5054255756 @default.
• W2109388713 creator A5073398031 @default.
• W2109388713 creator A5081255056 @default.
• W2109388713 date "2003-03-05" @default.
• W2109388713 modified "2023-10-10" @default.
• W2109388713 title "Role of the Estrogen Receptor Coactivator AIB1 (SRC-3) and HER-2/neu in Tamoxifen Resistance in Breast Cancer" @default.
• W2109388713 cites W1520299947 @default.
• W2109388713 cites W1613446635 @default.
• W2109388713 cites W1892496998 @default.
• W2109388713 cites W1950270470 @default.
• W2109388713 cites W1966714873 @default.
• W2109388713 cites W1980611435 @default.
• W2109388713 cites W1981022538 @default.
• W2109388713 cites W1987584174 @default.
• W2109388713 cites W2004693593 @default.
• W2109388713 cites W2014268944 @default.
• W2109388713 cites W2040361144 @default.
• W2109388713 cites W2045389096 @default.
• W2109388713 cites W2058777032 @default.
• W2109388713 cites W2060128629 @default.
• W2109388713 cites W2072787342 @default.
• W2109388713 cites W2073133361 @default.
• W2109388713 cites W2075094370 @default.
• W2109388713 cites W2076229177 @default.
• W2109388713 cites W2081218744 @default.
• W2109388713 cites W2097134216 @default.
• W2109388713 cites W2111650618 @default.
• W2109388713 cites W2114167623 @default.
• W2109388713 cites W2128003724 @default.
• W2109388713 cites W2151463503 @default.
• W2109388713 cites W2187668060 @default.
• W2109388713 cites W2289353246 @default.
• W2109388713 cites W2291927913 @default.
• W2109388713 cites W2343796556 @default.
• W2109388713 cites W4241870034 @default.
• W2109388713 cites W4252626281 @default.
• W2109388713 cites W4253138709 @default.
• W2109388713 cites W4254864035 @default.
• W2109388713 cites W4293241248 @default.
• W2109388713 cites W8163034 @default.
• W2109388713 doi "https://doi.org/10.1093/jnci/95.5.353" @default.
• W2109388713 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12618500" @default.
• W2109388713 hasPublicationYear "2003" @default.
• W2109388713 type Work @default.
• W2109388713 sameAs 2109388713 @default.
• W2109388713 citedByCount "730" @default.
• W2109388713 countsByYear W21093887132012 @default.
• W2109388713 countsByYear W21093887132013 @default.
• W2109388713 countsByYear W21093887132014 @default.
• W2109388713 countsByYear W21093887132015 @default.
• W2109388713 countsByYear W21093887132016 @default.
• W2109388713 countsByYear W21093887132017 @default.
• W2109388713 countsByYear W21093887132018 @default.
• W2109388713 countsByYear W21093887132019 @default.
• W2109388713 countsByYear W21093887132020 @default.
• W2109388713 countsByYear W21093887132021 @default.
• W2109388713 countsByYear W21093887132022 @default.
• W2109388713 countsByYear W21093887132023 @default.
• W2109388713 crossrefType "journal-article" @default.
• W2109388713 hasAuthorship W2109388713A5004386291 @default.
• W2109388713 hasAuthorship W2109388713A5006635460 @default.
• W2109388713 hasAuthorship W2109388713A5017963342 @default.
• W2109388713 hasAuthorship W2109388713A5026576818 @default.
• W2109388713 hasAuthorship W2109388713A5027914471 @default.
• W2109388713 hasAuthorship W2109388713A5030115311 @default.
• W2109388713 hasAuthorship W2109388713A5047798037 @default.
• W2109388713 hasAuthorship W2109388713A5054255756 @default.
• W2109388713 hasAuthorship W2109388713A5073398031 @default.
• W2109388713 hasAuthorship W2109388713A5081255056 @default.
• W2109388713 hasConcept C104317684 @default.
• W2109388713 hasConcept C121608353 @default.
• W2109388713 hasConcept C126322002 @default.
• W2109388713 hasConcept C134018914 @default.
• W2109388713 hasConcept C143998085 @default.
• W2109388713 hasConcept C2776067312 @default.
• W2109388713 hasConcept C2777176818 @default.
• W2109388713 hasConcept C2777982462 @default.
• W2109388713 hasConcept C50382708 @default.
• W2109388713 hasConcept C530470458 @default.
• W2109388713 hasConcept C55493867 @default.
• W2109388713 hasConcept C71924100 @default.
• W2109388713 hasConcept C77445288 @default.
• W2109388713 hasConcept C84606932 @default.
• W2109388713 hasConcept C86339819 @default.
• W2109388713 hasConcept C86803240 @default.
• W2109388713 hasConceptScore W2109388713C104317684 @default.
• W2109388713 hasConceptScore W2109388713C121608353 @default.
• W2109388713 hasConceptScore W2109388713C126322002 @default.
• W2109388713 hasConceptScore W2109388713C134018914 @default.

• next