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• W2109392391 abstract "Background We report a double-blind, randomized clinical trial of intracoronary β-radiation for prevention of restenosis after stent implantation in native coronary de novo lesions in diabetic patients. Methods After successful stent implantation in native coronary de novo lesions, 106 lesions in 89 diabetic patients were randomly allocated to treatment with β-radiation with 18 Gy at 1 mm vessel depth (n=53) or placebo treatment (n=53). Results Angiographic analysis at 9 month follow-up revealed a late lumen loss of 0.7±0.9 mm in the radiotherapy group versus 1.2±0.8 mm in the control group at the injured segment (P=0.006), 0.9±1.0 versus 1.3±0.7 mm at the radiated segment (P=0.02), and 0.9±1.0 versus 1.3±0.7 mm at the target segment (P=0.04) (defined as active source length plus 5 mm on proximal and distal sites). Binary restenosis rates were significantly lower in the radiation group in all subsegments (injured segment: 10.9 versus 37.3%, P=0.003; radiated segment: 21.7 versus 49.0%, P=0.005; target segment: 23.9 versus 49.0%, P=0.01). Target lesion revascularization for restenosis was required in nine lesions (17.6%) in the radiotherapy group versus 18 (34.0%) in the placebo group (P=0.05). Late thrombosis occurred in four radiated patients (after premature discontinuation of antiplatelet therapy in all), resulting in a major adverse clinical event rate of 37.2% in the brachytherapy group versus 38.6% in the placebo group (P=ns). Conclusions In diabetic patients with de novo coronary lesions, intracoronary radiation after stent implantation significantly reduced restenosis. However, this clinical benefit was reduced by the frequent occurrence of late thrombosis." @default.
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• W2109392391 date "2006-01-01" @default.
• W2109392391 modified "2023-09-23" @default.
• W2109392391 title "Randomized blinded clinical trial of intracoronary brachytherapy with 90Sr/Y beta-radiation for the prevention of restenosis after stent implantation in native coronary arteries in diabetic patients" @default.
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• W2109392391 doi "https://doi.org/10.1016/j.radonc.2005.10.012" @default.
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