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• W2109402169 abstract "BackgroundAggregatibacter actinomycetemcomitans serotypes are clearly associated with periodontitis or health, which suggests distinct strategies for survival within the host.ObjectiveWe investigated the transcription profile of virulence-associated genes in A. actinomycetemcomitans serotype b (JP2 and SUNY 465) strains associated with disease and serotype a (ATCC 29523) strain associated with health.DesignBacteria were co-cultured with immortalized gingival epithelial cells (OBA-9). The adhesion efficiency after 2 hours and the relative transcription of 13 genes were evaluated after 2 and 24 hours of interaction.ResultsAll strains were able to adhere to OBA-9, and this contact induced transcription of pgA for polysaccharide biosynthesis in all tested strains. Genes encoding virulence factors as Omp29, Omp100, leukotoxin, and CagE (apoptotic protein) were more transcribed by serotype b strains than by serotype a. ltxA and omp29, encoding the leukotoxin and the highly antigenic Omp29, were induced in serotype b by interaction with epithelial cells. Factors related to colonization (aae, flp, apaH, and pgA) and cdtB were upregulated in serotype a strain after prolonged interaction with OBA-9.ConclusionGenes relevant for surface colonization and interaction with the immune system are regulated differently among the strains, which may help explaining their differences in association with disease." @default.
• W2109402169 created "2016-06-24" @default.
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• W2109402169 date "2013-01-01" @default.
• W2109402169 modified "2023-09-27" @default.
• W2109402169 title "Differential transcription of virulence genes in <i>Aggregatibacter actinomycetemcomitans</i> serotypes" @default.
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• W2109402169 doi "https://doi.org/10.3402/jom.v5i0.21473" @default.
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