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- W2109415023 endingPage "e63188" @default.
- W2109415023 startingPage "e63188" @default.
- W2109415023 abstract "Membrane separation of biomolecules and their application in biocatalysis is becoming increasingly important for biotechnology, demanding the development of new biocompatible materials with novel properties. In the present study, an entirely noncovalent water-based material is used as a membrane for size-selective separation, immobilization, and biocatalytic utilization of proteins. The membrane shows stable performance under physiological conditions, allowing filtration of protein mixtures with a 150 kDa molecular weight cutoff (∼8 nm hydrodynamic diameter cutoff). Due to the biocompatibility of the membrane, filtered proteins stay functionally active and retained proteins can be partially recovered. Upon filtration, large enzymes become immobilized within the membrane. They exhibit stable activity when subjected to a constant flux of substrates for prolonged periods of time, which can be used to carry out heterogeneous biocatalysis. The noncovalent membrane material can be easily disassembled, purified, reassembled, and reused, showing reproducible performance after recycling. The robustness, recyclability, versatility, and biocompatibility of the supramolecular membrane may open new avenues for manipulating biological systems." @default.
- W2109415023 created "2016-06-24" @default.
- W2109415023 creator A5022917512 @default.
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- W2109415023 creator A5046185337 @default.
- W2109415023 creator A5072554655 @default.
- W2109415023 creator A5079107653 @default.
- W2109415023 date "2013-05-10" @default.
- W2109415023 modified "2023-10-16" @default.
- W2109415023 title "Separation, Immobilization, and Biocatalytic Utilization of Proteins by a Supramolecular Membrane" @default.
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- W2109415023 doi "https://doi.org/10.1371/journal.pone.0063188" @default.
- W2109415023 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3651134" @default.
- W2109415023 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23675461" @default.
- W2109415023 hasPublicationYear "2013" @default.
- W2109415023 type Work @default.