Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109431353> ?p ?o ?g. }
- W2109431353 endingPage "307" @default.
- W2109431353 startingPage "301" @default.
- W2109431353 abstract "The histopathology of airway inflammation in rare cases of sudden asphyxic asthma death (SAAD) is unclear. This study examines, for the first time, the relative disposition of lymphocyte and macrophage subsets and eosinophils in proximal and distal tissues of such cases. Multiple resection specimens from five cases of SAAD were studied. Tissue blocks were obtained at necroscopy and immediately frozen in liquid nitrogen within 18 hours of death (death occurring within 1 h of the onset of an unprovoked asphyxic asthma attack). After immunohistological staining, frozen sections underwent semi-quantitative analysis (cell counts per unit area) for T-cells, macrophages and eosinophils using computerized imaging systems. Subsets of T-cells and macrophages were estimated using double immunofluorescence techniques. Variability within samples, between samples and between cases was compared. These cases of fatal asthma showed infiltrates of T-cells, macrophages and eosinophils within peribronchial tissues. Distinct from stable asthma, a CD8+ T-cell dominance was found. A high proportion of eosinophils were activated (EG2+), whereas the relative proportion of antigen-presenting cells (RFD1+) did not seem to be abnormal, although numbers of these cells were high. These features were seen both in proximal and distal tissues. The variability of these parameters within an individual was 9.4-15.2%, however, the variability between individual cases was greater. Sudden asphyxic asthma is associated with inflammatory infiltrates both of proximal and distal lung tissues. In contrast to stable asthma, this infiltrate contains large numbers of CD8+ T-cells, suggesting distinct qualitative as well as quantitative characteristics in the immunopathology of sudden asthma death." @default.
- W2109431353 created "2016-06-24" @default.
- W2109431353 creator A5000251366 @default.
- W2109431353 creator A5012938629 @default.
- W2109431353 creator A5029053668 @default.
- W2109431353 creator A5042289288 @default.
- W2109431353 creator A5061402126 @default.
- W2109431353 creator A5078872265 @default.
- W2109431353 creator A5083608773 @default.
- W2109431353 date "1997-02-01" @default.
- W2109431353 modified "2023-10-13" @default.
- W2109431353 title "Lung immunopathology in cases of sudden asthma death" @default.
- W2109431353 cites W1842322809 @default.
- W2109431353 cites W1927802853 @default.
- W2109431353 cites W1968723792 @default.
- W2109431353 cites W1986892025 @default.
- W2109431353 cites W1993980339 @default.
- W2109431353 cites W1994106142 @default.
- W2109431353 cites W1995266481 @default.
- W2109431353 cites W2002089165 @default.
- W2109431353 cites W2006792226 @default.
- W2109431353 cites W2017715368 @default.
- W2109431353 cites W2023546187 @default.
- W2109431353 cites W2031121806 @default.
- W2109431353 cites W2039355506 @default.
- W2109431353 cites W2043878005 @default.
- W2109431353 cites W2057585969 @default.
- W2109431353 cites W2072974313 @default.
- W2109431353 cites W2074326572 @default.
- W2109431353 cites W2075215508 @default.
- W2109431353 cites W2110817651 @default.
- W2109431353 cites W2114805324 @default.
- W2109431353 cites W2120794083 @default.
- W2109431353 cites W2130217674 @default.
- W2109431353 cites W2165981929 @default.
- W2109431353 cites W92995244 @default.
- W2109431353 doi "https://doi.org/10.1183/09031936.97.10020301" @default.
- W2109431353 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9042624" @default.
- W2109431353 hasPublicationYear "1997" @default.
- W2109431353 type Work @default.
- W2109431353 sameAs 2109431353 @default.
- W2109431353 citedByCount "126" @default.
- W2109431353 countsByYear W21094313532012 @default.
- W2109431353 countsByYear W21094313532013 @default.
- W2109431353 countsByYear W21094313532014 @default.
- W2109431353 countsByYear W21094313532015 @default.
- W2109431353 countsByYear W21094313532016 @default.
- W2109431353 countsByYear W21094313532017 @default.
- W2109431353 countsByYear W21094313532018 @default.
- W2109431353 countsByYear W21094313532019 @default.
- W2109431353 countsByYear W21094313532020 @default.
- W2109431353 countsByYear W21094313532021 @default.
- W2109431353 countsByYear W21094313532022 @default.
- W2109431353 countsByYear W21094313532023 @default.
- W2109431353 crossrefType "journal-article" @default.
- W2109431353 hasAuthorship W2109431353A5000251366 @default.
- W2109431353 hasAuthorship W2109431353A5012938629 @default.
- W2109431353 hasAuthorship W2109431353A5029053668 @default.
- W2109431353 hasAuthorship W2109431353A5042289288 @default.
- W2109431353 hasAuthorship W2109431353A5061402126 @default.
- W2109431353 hasAuthorship W2109431353A5078872265 @default.
- W2109431353 hasAuthorship W2109431353A5083608773 @default.
- W2109431353 hasBestOaLocation W21094313531 @default.
- W2109431353 hasConcept C126322002 @default.
- W2109431353 hasConcept C142724271 @default.
- W2109431353 hasConcept C147483822 @default.
- W2109431353 hasConcept C159654299 @default.
- W2109431353 hasConcept C167672396 @default.
- W2109431353 hasConcept C202751555 @default.
- W2109431353 hasConcept C203014093 @default.
- W2109431353 hasConcept C2776042228 @default.
- W2109431353 hasConcept C2776178081 @default.
- W2109431353 hasConcept C2777714996 @default.
- W2109431353 hasConcept C2778236600 @default.
- W2109431353 hasConcept C2779244956 @default.
- W2109431353 hasConcept C2780648854 @default.
- W2109431353 hasConcept C544855455 @default.
- W2109431353 hasConcept C55493867 @default.
- W2109431353 hasConcept C71924100 @default.
- W2109431353 hasConcept C86803240 @default.
- W2109431353 hasConcept C95798472 @default.
- W2109431353 hasConceptScore W2109431353C126322002 @default.
- W2109431353 hasConceptScore W2109431353C142724271 @default.
- W2109431353 hasConceptScore W2109431353C147483822 @default.
- W2109431353 hasConceptScore W2109431353C159654299 @default.
- W2109431353 hasConceptScore W2109431353C167672396 @default.
- W2109431353 hasConceptScore W2109431353C202751555 @default.
- W2109431353 hasConceptScore W2109431353C203014093 @default.
- W2109431353 hasConceptScore W2109431353C2776042228 @default.
- W2109431353 hasConceptScore W2109431353C2776178081 @default.
- W2109431353 hasConceptScore W2109431353C2777714996 @default.
- W2109431353 hasConceptScore W2109431353C2778236600 @default.
- W2109431353 hasConceptScore W2109431353C2779244956 @default.
- W2109431353 hasConceptScore W2109431353C2780648854 @default.
- W2109431353 hasConceptScore W2109431353C544855455 @default.
- W2109431353 hasConceptScore W2109431353C55493867 @default.
- W2109431353 hasConceptScore W2109431353C71924100 @default.
- W2109431353 hasConceptScore W2109431353C86803240 @default.