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- W2109432887 abstract "The first steps of ether lipid biosynthesis are exclusively localized to peroxisomes and hence some peroxisomal disorders are characterized by a severe deficiency of plasmalogens, the main ether lipids in humans. Here we report on gene defects of plasmalogen biosynthesis, chromosomal localization of the corresponding genes and, as a consequence of plasmalogen deficiency, on structural alterations of caveolae, clathrin-coated pits, endoplasmic reticulum and Golgi cisternae, as well as on the reduced rate of transferrin receptor cycling. The data suggest that plasmalogens, analogous to cholesterol, are essential for correct membrane functioning and their deficiency results in impaired membrane trafficking." @default.
- W2109432887 created "2016-06-24" @default.
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- W2109432887 date "2001-01-01" @default.
- W2109432887 modified "2023-10-15" @default.
- W2109432887 title "Impaired membrane traffic in defective ether lipid biosynthesis" @default.
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- W2109432887 doi "https://doi.org/10.1093/hmg/10.2.127" @default.
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