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• W2109441092 abstract "ABSTRACT Few data are available on the molecular subtypes of all penicillin-nonsusceptible Streptococcus pneumoniae (PNSP) from a defined population base. Pulsed-field gel electrophoresis (PFGE), serotyping, and antibiotic susceptibility testing were performed for all available invasive PNSP isolates for which the penicillin (MIC) was ≥0.1 μg/ml from Baltimore, Md., during 1995–1996 ( n = 143). The dendrogram analysis of PFGE patterns included 32 distinct clonal groups. Six major clonal groups included two-thirds of the PNSP strains. Major clonal groups 2, 3, 4, and 6 strains were genetically related to four previously described international clones and were all multidrug resistant. Major clonal group 3 was genetically related to the Tennessee 23F -4 clone and contained all four strains for which the penicillin MIC was 8 μg/ml. Most of the clonal group 1 and 5 strains had intermediate susceptibility to penicillin and were rarely multidrug resistant. The latter clonal groups represent two previously undescribed penicillin-intermediate pneumococcal clones. Clonal group homogeneity was greater for serotype 9V, 19A, and 23F strains than for serotype 6A, 6B, 14, and 19F strains. The classification of PNSP strains into clonal groups is essential for future population-based epidemiologic studies of PNSP." @default.
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• W2109441092 date "2000-12-01" @default.
• W2109441092 modified "2023-10-16" @default.
• W2109441092 title "Clonal Groups of Penicillin-Nonsusceptible Streptococcus pneumoniae in Baltimore, Maryland: a Population-Based, Molecular Epidemiologic Study" @default.
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• W2109441092 doi "https://doi.org/10.1128/jcm.38.12.4367-4372.2000" @default.
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