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- W2109441383 abstract "Inconsistent results are available upon natural killer (NK) cell cytotoxicity in Alzheimer's disease. Number of NK effectors and levels of activity have been reported elevated, reduced or normal, as well as responses to cytokines. A longitudinal study was designed to address the clinical applicability of NK cell activity as prognostic factors in Alzheimer's disease. NK cell activity of peripheral blood mononuclear (PBM) cells is being measured in 19 subjects (age range; 61–84 years old) with mild senile dementia of Alzheimer's type (SDAT) chosen for short history of disease and no medication at baseline. Each subject is paired to an age- and sex-matched healthy control. Levels of cytotoxicity at baseline and after PBM cell exposure to modifiers either negative (cortisol 10 -6 M) or positive (rIL-2 650 IU/ml) are being measured at time of enrolment (T0), 6 months (T1), 12 months (T2), 18 months (T3), 24 months (T4), 30 months (T5), 36 months (T6). Lymphocyte subsets are determined using flow cytometry at the same time points. Spontaneous NK cell activity was not significantly different in SDAT subjects vs controls at T0. In vitro inhibition by cortisol was lower in SDAT (P<0.05); cytokine-induced changes were greater (rIL-2, P<0.02). Data indicate that SDAT subjects show abnormal responsiveness of NK cell activity to physiological modifiers while maintaining normal spontaneous activity at least at onset of disease. NK cell activity increased sharply at T1 and declined significantly at later time-points. Although changes might be related to increasing age, NK cell activity showed a lower increase in SDAT at T1 than in controls. Responsivity to cortisol declined significantly in SDAT with progression of disease, while it remained unchanged in controls. Our data at baseline are compatible with partial glucocorticoid resistance at the immune level. Our longitudinal study is exploring whether changes in responsivity of NK cells to modifiers follows progression of disease. Ourfindings are likely to confirm our hypothesis. NK cell responsivity to immune modifiers might be a quite inexpensive and easy accessible tool in the risk assessment, early diagnosis and follow-up of SDAT." @default.
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- W2109441383 date "2005-07-01" @default.
- W2109441383 modified "2023-10-16" @default.
- W2109441383 title "[P-014]: Natural killer (NK) cell activity as an early marker of Alzheimer's disease: Results from a three year follow-up study" @default.
- W2109441383 doi "https://doi.org/10.1016/j.jalz.2005.06.076" @default.
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