Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109442939> ?p ?o ?g. }
Showing items 1 to 99 of
99
with 100 items per page.
- W2109442939 endingPage "e28" @default.
- W2109442939 startingPage "e24" @default.
- W2109442939 abstract "We previously reported that acute myelogenous leukemia (AML) transplants using killer cell immunoglobulin-type receptor (KIR) B haplotype better or best (≥2 B activating gene loci ± Cen B/B) unrelated donors (URDs) yield less relapse and better survival. In this prospective trial we evaluated 535 AML searches from 14 participating centers with centralized donor KIR genotyping for donor selection. This represented 3% to 48% of all AML searches (median 20%) per center, totaling 3 to 172 patients (median 22) per center. Donor KIR genotype was reported at a median of 14 days after request (≤26 days for 76% of searches). In 535 searches, 2080 donors were requested for KIR genotyping (mean 4.3 per search); and a median of 1.8 (range, 0 to 4.5) per search were KIR typed. Choosing more donors for confirmatory HLA and KIR haplotype identification enriched the likelihood of finding KIR better or best donors. The search process identified a mean of 30% KIR better or best donors; the success ranged from 24% to 38% in the 11 centers enrolling ≥8 patients. More donors requested for KIR genotyping increased the likelihood of identifying KIR better or best haplotype donors. Of the 247 transplants, 9.3% used KIR best, 19% used KIR better, and 48% used KIR neutral donors while 24% used a non–KIR-tested donor. KIR genotyping did not delay transplantation. The time from search to transplant was identical for transplants using a KIR-genotyped versus a non–KIR-genotyped donor. Prospective evaluation can rapidly identify KIR favorable genotype donors, but choosing more donors per search would substantially increase the likelihood of having a KIR best or better donor available for transplantation. Transplant centers and donor registries must both commit extra effort to incorporate new characteristics (beyond HLA, age, and parity) into improved donor selection. Deliberate efforts to present additional genetic factors for donor selection will require novel procedures." @default.
- W2109442939 created "2016-06-24" @default.
- W2109442939 creator A5008876887 @default.
- W2109442939 date "2011-06-01" @default.
- W2109442939 modified "2023-09-25" @default.
- W2109442939 title "Lung transplantation for bronchiectasis due to smoke inhalation" @default.
- W2109442939 cites W1494700145 @default.
- W2109442939 cites W168698601 @default.
- W2109442939 cites W1977078085 @default.
- W2109442939 cites W1979676940 @default.
- W2109442939 cites W1983196508 @default.
- W2109442939 cites W1986824630 @default.
- W2109442939 cites W1996303101 @default.
- W2109442939 cites W1996869743 @default.
- W2109442939 cites W2002415245 @default.
- W2109442939 cites W2004487155 @default.
- W2109442939 cites W2020106882 @default.
- W2109442939 cites W2022497670 @default.
- W2109442939 cites W2024582353 @default.
- W2109442939 cites W2025783426 @default.
- W2109442939 cites W2028056135 @default.
- W2109442939 cites W2030015146 @default.
- W2109442939 cites W2038485127 @default.
- W2109442939 cites W2047335037 @default.
- W2109442939 cites W2049610471 @default.
- W2109442939 cites W2050270353 @default.
- W2109442939 cites W2055021440 @default.
- W2109442939 cites W2055476019 @default.
- W2109442939 cites W2067818727 @default.
- W2109442939 cites W2074701144 @default.
- W2109442939 cites W2081078817 @default.
- W2109442939 cites W2090435503 @default.
- W2109442939 cites W2091954926 @default.
- W2109442939 cites W2109119240 @default.
- W2109442939 cites W2146489617 @default.
- W2109442939 cites W2156091908 @default.
- W2109442939 cites W2156391668 @default.
- W2109442939 cites W2156883447 @default.
- W2109442939 cites W2297133168 @default.
- W2109442939 cites W2302866545 @default.
- W2109442939 cites W2470574760 @default.
- W2109442939 cites W3023225830 @default.
- W2109442939 cites W4376205 @default.
- W2109442939 cites W44033292 @default.
- W2109442939 cites W903580173 @default.
- W2109442939 doi "https://doi.org/10.1016/j.burns.2011.01.011" @default.
- W2109442939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21334828" @default.
- W2109442939 hasPublicationYear "2011" @default.
- W2109442939 type Work @default.
- W2109442939 sameAs 2109442939 @default.
- W2109442939 citedByCount "2" @default.
- W2109442939 countsByYear W21094429392016 @default.
- W2109442939 countsByYear W21094429392017 @default.
- W2109442939 crossrefType "journal-article" @default.
- W2109442939 hasAuthorship W2109442939A5008876887 @default.
- W2109442939 hasConcept C104317684 @default.
- W2109442939 hasConcept C126322002 @default.
- W2109442939 hasConcept C135763542 @default.
- W2109442939 hasConcept C197754878 @default.
- W2109442939 hasConcept C203014093 @default.
- W2109442939 hasConcept C2781448352 @default.
- W2109442939 hasConcept C2911091166 @default.
- W2109442939 hasConcept C31467283 @default.
- W2109442939 hasConcept C54355233 @default.
- W2109442939 hasConcept C71924100 @default.
- W2109442939 hasConcept C86803240 @default.
- W2109442939 hasConceptScore W2109442939C104317684 @default.
- W2109442939 hasConceptScore W2109442939C126322002 @default.
- W2109442939 hasConceptScore W2109442939C135763542 @default.
- W2109442939 hasConceptScore W2109442939C197754878 @default.
- W2109442939 hasConceptScore W2109442939C203014093 @default.
- W2109442939 hasConceptScore W2109442939C2781448352 @default.
- W2109442939 hasConceptScore W2109442939C2911091166 @default.
- W2109442939 hasConceptScore W2109442939C31467283 @default.
- W2109442939 hasConceptScore W2109442939C54355233 @default.
- W2109442939 hasConceptScore W2109442939C71924100 @default.
- W2109442939 hasConceptScore W2109442939C86803240 @default.
- W2109442939 hasIssue "4" @default.
- W2109442939 hasLocation W21094429391 @default.
- W2109442939 hasLocation W21094429392 @default.
- W2109442939 hasOpenAccess W2109442939 @default.
- W2109442939 hasPrimaryLocation W21094429391 @default.
- W2109442939 hasRelatedWork W1973065959 @default.
- W2109442939 hasRelatedWork W2112946603 @default.
- W2109442939 hasRelatedWork W2120212735 @default.
- W2109442939 hasRelatedWork W2127562786 @default.
- W2109442939 hasRelatedWork W2339460042 @default.
- W2109442939 hasRelatedWork W2420275792 @default.
- W2109442939 hasRelatedWork W2810318307 @default.
- W2109442939 hasRelatedWork W2905782781 @default.
- W2109442939 hasRelatedWork W2914362656 @default.
- W2109442939 hasRelatedWork W4311188434 @default.
- W2109442939 hasVolume "37" @default.
- W2109442939 isParatext "false" @default.
- W2109442939 isRetracted "false" @default.
- W2109442939 magId "2109442939" @default.
- W2109442939 workType "article" @default.