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- W2109451337 abstract "The purpose of the present investigation was to study the effect of delay in fixation on the mitotic activity in tumour tissue. A human osteogenic sarcoma, especially suitable for counting of mitoses, grown in athymic nude mice, was fixed with varying delay and the mitotic, prophase, metaphase and ana-telophase indices were determined. An almost exponential decline of the mitotic index was observed with a reduction to 49.4% and 15.0% after respectively 60 and 180 minutes. The proportional incidence of prophases, metaphases and ana-telophases changed so that a relative accummulation of advanced phases occured during the 180 minutes of observation. It is concluded that delay in fixation of a magnitude, which is not uncommon in routine surgical pathology, may allow the majority of mitoses to terminate, resulting in unreliable assessments of mitotic activity." @default.
- W2109451337 created "2016-06-24" @default.
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- W2109451337 date "1979-07-01" @default.
- W2109451337 modified "2023-10-16" @default.
- W2109451337 title "MITOTIC ACTIVITY AND DELAY IN FIXATION OF TUMOUR TISSUE" @default.
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- W2109451337 doi "https://doi.org/10.1111/j.1699-0463.1979.tb00065.x" @default.
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