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• W2109452187 abstract "Abstract We present a new filter assay for the determination of glycohemoglobin as a unique application of the boronic acid affinity principle. With the use of a water-soluble blue-colored boronic acid derivative and a specific precipitation method for hemoglobin, total hemoglobin including bound boronic acid is precipitated and collected on a filter strip before quantification. Hemoglobin and boronic acid are quantified by a dual-wavelength reflectometric measurement, and the result is reported directly as percent glycohemoglobin. The test is simple, quick, and designed as a doctors’ office test for the monitoring and management of diabetes. The imprecision of the assay is &lt;4% over the range 3–18% Hb A1c, and the method is linear up to at least 20% Hb A1c. Comparisons with four well-established glycohemoglobin methods yielded correlation coefficients ranging from 0.94 to 0.99, with slopes from 0.94 to 1.01." @default.
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• W2109452187 date "1997-12-01" @default.
• W2109452187 modified "2023-09-26" @default.
• W2109452187 title "Glycohemoglobin filter assay for doctors’ offices based on boronic acid affinity principle" @default.
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• W2109452187 doi "https://doi.org/10.1093/clinchem/43.12.2390" @default.
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