Matches in SemOpenAlex for { <https://semopenalex.org/work/W2109453910> ?p ?o ?g. }
- W2109453910 endingPage "844" @default.
- W2109453910 startingPage "834" @default.
- W2109453910 abstract "The emergence of methicillin-resistant Staphylococcus aureus (MRSA) has created the need for better therapeutic options. In this study, five natural xanthones were extracted and purified from the fruit hull of Garcinia mangostana and their antimicrobial properties were investigated. α-Mangostin was identified as the most potent among them against Gram-positive pathogens (MIC = 0.78–1.56 μg/mL) which included two MRSA isolates. α‐Mangostin also exhibited rapid in vitro bactericidal activity (3-log reduction within 5 min). In a multistep (20 passage) resistance selection study using a MRSA isolated from the eye, no resistance against α-mangostin in the strains tested was observed. Biophysical studies using fluorescence probes for membrane potential and permeability, calcein encapsulated large unilamellar vesicles and scanning electron microscopy showed that α‐mangostin rapidly disrupted the integrity of the cytoplasmic membrane leading to loss of intracellular components in a concentration-dependent manner. Molecular dynamic simulations revealed that isoprenyl groups were important to reduce the free energy for the burial of the hydrophobic phenyl ring of α-mangostin into the lipid bilayer of the membrane resulting in membrane breakdown and increased permeability. Thus, we suggest that direct interactions of α-mangostin with the bacterial membrane are responsible for the rapid concentration-dependent membrane disruption and bactericidal action." @default.
- W2109453910 created "2016-06-24" @default.
- W2109453910 creator A5007551999 @default.
- W2109453910 creator A5012659849 @default.
- W2109453910 creator A5026163161 @default.
- W2109453910 creator A5030882666 @default.
- W2109453910 creator A5031514811 @default.
- W2109453910 creator A5035157534 @default.
- W2109453910 creator A5045760818 @default.
- W2109453910 creator A5048275793 @default.
- W2109453910 creator A5050427903 @default.
- W2109453910 creator A5065536926 @default.
- W2109453910 creator A5077793881 @default.
- W2109453910 creator A5089009658 @default.
- W2109453910 creator A5089738575 @default.
- W2109453910 date "2013-02-01" @default.
- W2109453910 modified "2023-10-15" @default.
- W2109453910 title "Rapid bactericidal action of alpha-mangostin against MRSA as an outcome of membrane targeting" @default.
- W2109453910 cites W1558103114 @default.
- W2109453910 cites W1970923132 @default.
- W2109453910 cites W1971011514 @default.
- W2109453910 cites W1971252497 @default.
- W2109453910 cites W1978679680 @default.
- W2109453910 cites W1981463355 @default.
- W2109453910 cites W1982027539 @default.
- W2109453910 cites W1989456352 @default.
- W2109453910 cites W1995614441 @default.
- W2109453910 cites W1997025327 @default.
- W2109453910 cites W1997337616 @default.
- W2109453910 cites W1997662122 @default.
- W2109453910 cites W1998381292 @default.
- W2109453910 cites W2006431667 @default.
- W2109453910 cites W2008757158 @default.
- W2109453910 cites W2015462238 @default.
- W2109453910 cites W2016366979 @default.
- W2109453910 cites W2016567759 @default.
- W2109453910 cites W2016763331 @default.
- W2109453910 cites W2024821551 @default.
- W2109453910 cites W2027912106 @default.
- W2109453910 cites W2030003715 @default.
- W2109453910 cites W2036628662 @default.
- W2109453910 cites W2037788435 @default.
- W2109453910 cites W2052038479 @default.
- W2109453910 cites W2069289075 @default.
- W2109453910 cites W2070517369 @default.
- W2109453910 cites W2074232920 @default.
- W2109453910 cites W2083183071 @default.
- W2109453910 cites W2084037807 @default.
- W2109453910 cites W2084845164 @default.
- W2109453910 cites W2097638025 @default.
- W2109453910 cites W2100517092 @default.
- W2109453910 cites W2111667046 @default.
- W2109453910 cites W2115550568 @default.
- W2109453910 cites W2118378514 @default.
- W2109453910 cites W2121842616 @default.
- W2109453910 cites W2123909174 @default.
- W2109453910 cites W2125066910 @default.
- W2109453910 cites W2127522551 @default.
- W2109453910 cites W2130290558 @default.
- W2109453910 cites W2131316809 @default.
- W2109453910 cites W2133084204 @default.
- W2109453910 cites W2133902131 @default.
- W2109453910 cites W2133973200 @default.
- W2109453910 cites W2135235427 @default.
- W2109453910 cites W2136277094 @default.
- W2109453910 cites W2139101850 @default.
- W2109453910 cites W2146894318 @default.
- W2109453910 cites W2153862539 @default.
- W2109453910 cites W2153998069 @default.
- W2109453910 cites W2157486329 @default.
- W2109453910 cites W2160884845 @default.
- W2109453910 cites W2165453779 @default.
- W2109453910 cites W2166286523 @default.
- W2109453910 cites W2166791780 @default.
- W2109453910 cites W2166920417 @default.
- W2109453910 cites W2168674774 @default.
- W2109453910 cites W2315594095 @default.
- W2109453910 cites W4251696101 @default.
- W2109453910 doi "https://doi.org/10.1016/j.bbamem.2012.09.004" @default.
- W2109453910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22982495" @default.
- W2109453910 hasPublicationYear "2013" @default.
- W2109453910 type Work @default.
- W2109453910 sameAs 2109453910 @default.
- W2109453910 citedByCount "138" @default.
- W2109453910 countsByYear W21094539102012 @default.
- W2109453910 countsByYear W21094539102013 @default.
- W2109453910 countsByYear W21094539102014 @default.
- W2109453910 countsByYear W21094539102015 @default.
- W2109453910 countsByYear W21094539102016 @default.
- W2109453910 countsByYear W21094539102017 @default.
- W2109453910 countsByYear W21094539102018 @default.
- W2109453910 countsByYear W21094539102019 @default.
- W2109453910 countsByYear W21094539102020 @default.
- W2109453910 countsByYear W21094539102021 @default.
- W2109453910 countsByYear W21094539102022 @default.
- W2109453910 countsByYear W21094539102023 @default.
- W2109453910 crossrefType "journal-article" @default.
- W2109453910 hasAuthorship W2109453910A5007551999 @default.