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• W2109454031 startingPage "E1159" @default.
• W2109454031 abstract "The Elovl3 gene, which putatively encodes for a protein involved in the elongation of saturated and monounsaturated fatty acids in the C20-C24 range, is expressed in murine liver, skin, and brown adipose tissue (BAT). In BAT, Elovl3 is dramatically upregulated during tissue activation in response to cold exposure, and functional data imply that ELOVL3 is a critical enzyme for lipid accumulation in brown adipocytes during the early phase of tissue recruitment. The activation of BAT is controlled by sympathetic nerve activity and norepinephrine release. By using primary cultures of brown adipocytes, we show here that the induced Elovl3 gene expression is synergistically regulated by norepinephrine and the peroxisome proliferator-activated receptor (PPAR) gamma ligand rosiglitazone. In addition, the potency of rosiglitazone to induce Elovl3 expression was several orders of magnitude higher than for the PPARalpha and PPARdelta ligands WY-14643 and L-165041, respectively. The maximal increase in mRNA level by norepinephrine and rosiglitazone is achieved by induced transcription as well as increased mRNA stability, and the whole process requires novel protein synthesis. We conclude that norepinehrine and PPARgamma, despite having different roles in brown adipocyte activation and differentiation, cooperate in expanding the intracellular lipid pool by synergistically stimulating Elovl3 expression." @default.
• W2109454031 created "2016-06-24" @default.
• W2109454031 creator A5015266255 @default.
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• W2109454031 date "2007-11-01" @default.
• W2109454031 modified "2023-09-23" @default.
• W2109454031 title "Norepinephrine and rosiglitazone synergistically induce<i>Elovl3</i>expression in brown adipocytes" @default.
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• W2109454031 doi "https://doi.org/10.1152/ajpendo.00213.2007" @default.
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